CAS 862073-77-6

Herkinorin

Description:

Herkinorin is a synthetic compound that belongs to the class of opioid receptor agonists. It is primarily known for its selective activity at the mu-opioid receptor, which is responsible for mediating analgesic effects. Structurally, Herkinorin is characterized by its unique molecular framework that allows it to interact with opioid receptors, potentially offering pain relief with a reduced risk of typical opioid side effects. Research indicates that Herkinorin may exhibit a lower propensity for inducing tolerance and dependence compared to traditional opioids, making it a subject of interest in pain management studies. Additionally, its pharmacological profile suggests potential applications in treating various pain conditions while minimizing adverse effects commonly associated with opioid use. However, further studies are necessary to fully understand its efficacy, safety, and therapeutic potential in clinical settings. As with any compound, the use of Herkinorin should be approached with caution, considering the complexities of opioid pharmacology and the potential for misuse.

Formula: C₂₈H₃₀O₈

InChI: InChI=1S/C28H30O8/c1-27-11-9-18-26(32)36-21(17-10-12-34-15-17)14-28(18,2)23(27)22(29)20(13-19(27)25(31)33-3)35-24(30)16-7-5-4-6-8-16/h4-8,10,12,15,18-21,23H,9,11,13-14H2,1-3H3/t18-,19-,20-,21-,23-,27-,28-/m0/s1

InChI key: InChIKey=PYDQMXRFUVDCHC-XAGHGKQISA-N

SMILES: C[C@@]12[C@@]3([C@](C)([C@H](C(OC)=O)C[C@H](OC(=O)C4=CC=CC=C4)C3=O)CC[C@]1(C(=O)O[C@@H](C2)C=5C=COC5)[H])[H]

Synonyms:

• Herkinorin
• 2H-Naphtho[2,1-c]pyran-7-carboxylic acid, 9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-, methyl ester, (2S,4aR,6aR,7R,9S,10aS,10bR)-

Herkinorin

CAS: 862073-77-6

Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.

Formula: C₂₈H₃₀O₈

Color and Shape: Solid

Molecular weight: 494.53

Ref: TM-T27534

Herkinorin

CAS: 862073-77-6

Herkinorin is a novel opioid analgesic that has been shown to have antinociceptive effects in the tail flick and hot plate tests. Herkinorin binds to the μ-opioid receptor with high affinity, which may be due to its similarity in structure to morphine. The binding of herkinorin to the μ-opioid receptor leads to an increase in cyclic adenosine monophosphate (cAMP) levels, which activates protein kinase A and inhibits phosphodiesterase. It has been shown that herkinorin can reverse the effects of nω-nitro-l-arginine methyl ester (L-NAME), a drug known for its negative effects on cAMP production, on rotarod performance in rats.

Formula: C₂₈H₃₀O₈

Purity: Min. 95%

Molecular weight: 494.5 g/mol

Ref: 3D-MJB07377