CAS 86220-42-0

Nafarelin Acetate

Description:

Nafarelin acetate is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH), primarily used in the treatment of hormone-sensitive conditions such as endometriosis and precocious puberty. It functions as a GnRH agonist, initially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), but with continuous administration, it leads to downregulation of the GnRH receptors, resulting in decreased gonadal hormone production. Nafarelin acetate is typically administered via a nasal spray or subcutaneous injection, allowing for effective systemic absorption. The compound is characterized by its ability to modulate hormonal levels, making it valuable in clinical settings. Its chemical structure includes a specific sequence of amino acids that contribute to its biological activity. Common side effects may include hot flashes, headaches, and changes in menstrual cycle patterns. Due to its hormonal effects, careful monitoring is essential during treatment to mitigate potential risks associated with long-term use. Overall, nafarelin acetate represents a significant therapeutic option in managing conditions influenced by hormonal imbalances.

Formula: C₆₈H₈₇N₁₇O₁₅

InChI: InChI=1/C66H83N17O13.C2H4O2/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46;1-2(3)4/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71);1H3,(H,3,4)/t46-,47-,48-,49-,50+,51-,52-,53-,54-;/m0./s1

Synonyms:

• Nafarelin acetate [USAN]
• 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate (salt) hydrate
• Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate
• Nafarelin acetate hydrate
• Rs-94991-298
• Luteinizing hormone-releasing factor (swine), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate
• NafarelinAcetate
• (2S)-N-(2-amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-(2-methylpropyl)-8-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide acetate (1:1) (non-preferred name)
• 5-Oxo-L-Prolyl-L-Histidyl-L-Tryptophyl-L-Seryl-L-Tyrosyl-3-(2-Naphthyl)-D-Alanyl-L-Leucyl-L-Arginyl-L-Prolylglycinamide Acetate Hydrate
• Nafarelin acetate

Nafarelin acetate salt hydrate

CAS: 86220-42-0

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 1322.47 (anhydrous free base)

Ref: 7W-GP2826

Nafarelin acetate hydrate

CAS: 86220-42-0

Nafarelin: a GnRH agonist used to treat endometriosis, precocious puberty, and control IVF. Delivered as a nasal spray. Marketed as Synarel by Pfizer.

Formula: C₆₆H₈₃N₁₇O₁₃·xC₂H₄O₂·xH₂O

Color and Shape: Solid

Molecular weight: 1400.563

Ref: TM-T68525