CAS 862543-54-2

maropitant citrate salt

Description:

Maropitant citrate salt is a chemical compound primarily used as an antiemetic agent in veterinary medicine, particularly for the prevention and treatment of vomiting in dogs and cats. It functions as a neurokinin-1 (NK1) receptor antagonist, effectively blocking the action of substance P, a neuropeptide involved in the vomiting reflex. This compound is characterized by its high solubility in water, which facilitates its administration in liquid formulations. Maropitant citrate salt is typically administered orally or via injection, and it has a favorable safety profile when used according to veterinary guidelines. The compound is also noted for its rapid onset of action, making it effective in acute situations. Additionally, maropitant has been studied for its potential use in other species and for various conditions beyond vomiting, although its primary application remains in the management of nausea and vomiting in companion animals. As with any medication, it is essential to follow veterinary advice regarding dosage and administration to ensure safety and efficacy.

Maropitant Citrate

CAS: 862543-54-2

Formula: C₃₂H₄₀N₂O·C₆H₈O₇

Color and Shape: White To Off-White Solid

Molecular weight: 468.69 192.12

Ref: 4Z-M-169001

Maropitant Citrate Salt

CAS: 862543-54-2

Applications Maropitant is a neurokinin type 1 (NK-1) receptor antagonist. Recent studies show that Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs.
References Boscan, P. et al.: Am. J. Vet. Res., 72, 1576 (2011);

Formula: C₃₂H₄₀N₂O·C₆H₈O₇

Color and Shape: Off White Solid

Molecular weight: 660.8

Ref: TR-M197300

Maropitant citrate

CAS: 862543-54-2

Maropitant citrate is a drug that has been shown to have clinical relevance in the treatment of chronic cough. It is a neurokinin-1 receptor antagonist that binds to the NK-1 receptor and blocks the effects of substance P. Maropitant citrate is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The terminal half-life of maropitant citrate is approximately 14 hours. The drug has low bioavailability due to its poor water solubility and high lipid solubility. This may be because it has a long fatty acid side chain that prevents its lipophilic properties from being fully utilized.

Formula: C₃₈H₄₈N₂O₈

Purity: Min. 95%

Molecular weight: 660.8 g/mol

Ref: 3D-MJB54354

Maropitant citrate anhydrous

CAS: 862543-54-2

Maropitant citrate anhydrous is a neurokinin (NK1) receptor antagonist.

Formula: C₃₈H₄₈N₂O₈

Color and Shape: Solid

Molecular weight: 660.8

Ref: TM-T68519