CAS 86303-23-3

deoxy-BIGCHAP

Description:

Deoxy-BIGCHAP, with the CAS number 86303-23-3, is a synthetic compound primarily used in biochemical research, particularly in the study of membrane proteins. It is a derivative of the well-known detergent BIGCHAP, which is utilized for solubilizing membrane proteins while maintaining their functional integrity. Deoxy-BIGCHAP is characterized by its ability to form micelles, which helps in stabilizing proteins in solution and facilitating their purification and analysis. The compound is non-ionic, which minimizes interference with protein interactions, making it suitable for various applications in structural biology and biochemistry. Its hydrophobic and hydrophilic balance allows it to effectively interact with lipid bilayers, aiding in the extraction of membrane proteins from cellular environments. Additionally, deoxy-BIGCHAP is often favored for its lower toxicity compared to other detergents, making it a valuable tool in laboratory settings. Overall, its unique properties contribute significantly to advancements in the understanding of membrane protein structure and function.

Formula: C₄₂H₇₅N₃O₁₅

InChI: InChI=1S/C42H75N3O15/c1-22(26-9-10-27-25-8-7-23-18-24(48)12-13-41(23,2)28(25)19-31(51)42(26,27)3)6-11-32(52)45(16-4-14-43-39(59)37(57)35(55)33(53)29(49)20-46)17-5-15-44-40(60)38(58)36(56)34(54)30(50)21-47/h22-31,33-38,46-51,53-58H,4-21H2,1-3H3,(H,43,59)(H,44,60)/t22-,23-,24-,25+,26-,27+,28+,29-,30-,31+,33-,34-,35+,36+,37-,38-,41+,42-/m1/s1

InChI key: InChIKey=OJSUWTDDXLCUFR-HGZMBBKESA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(N(CCCNC([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O)CCCNC([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O)=O)C)[H])[H]

Synonyms:

• (2R,3S,4R,5R)-N-[3-[[(4R)-4-[(3R,5S,8R,9S,10S,12S,13R,14R,17S)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]-[3-[[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoyl]amino]propyl]amino]propyl]-2,3,4,5,6-pentahydroxy-hexanamide
• <span class="text-smallcaps">D</span>-Gluconamide, N,N′-[[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]imino]di-3,1-propanediyl]bis-
• Cholane, <span class="text-smallcaps">D</span>-gluconamide deriv.
• N,N′-Bis(3-<span class="text-smallcaps">D</span>-gluconamidopropyl)deoxycholamide
• N,N′-[[[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]imino]di-3,1-propanediyl]bis[<span class="text-smallcaps">D</span>-gluconamide]
• deoxy-BIGCHAP
• Cholane, D-gluconamide deriv.
• N,N′-Bis(3-D-gluconamidopropyl)deoxycholamide
• N,N′-[[[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]imino]di-3,1-propanediyl]bis[D-gluconamide]
• D-Gluconamide, N,N′-[[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]imino]di-3,1-propanediyl]bis-

D-Gluconamide,N,N'-[[[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]imino]di-3,1-propanediyl]bis-

CAS: 86303-23-3

Formula: C₄₂H₇₅N₃O₁₅

Purity: 90%

Color and Shape: Solid

Molecular weight: 862.0560

Ref: IN-DA00IE04

N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide

CAS: 86303-23-3

Formula: C₄₂H₇₅N₃O₁₅

Molecular weight: 862.05

Ref: 7W-GL4808

Deoxy-bigchap

CAS: 86303-23-3

Deoxy-bigchap

Formula: C₄₂H₇₅N₃O₁₅

Purity: 90%

Color and Shape: white solid

Molecular weight: 862.06g/mol

Ref: 54-BIB1156

Deoxy-bigchap

CAS: 86303-23-3

Deoxy-bigchap

Color and Shape: White Powder

Molecular weight: 862.06g/mol

Ref: 54-OR2325T

Deoxy-Bigchap

Controlled Product

CAS: 86303-23-3

Stability Moisture Sensitive
Applications A nonionic detergent with properties comparable to CHAPS and CHAPSO but with reduced electrostatic interactions. Suited for ion exchange chromatography.
References Hjelmeland, L.M., et al.: Anal. Biochem., 130, 485 (1983), Buhler, H., et al.: Biochim. et Biophys. Acta., 1075, 206 (1991)

Formula: C₄₂H₇₅N₃O₁₅

Color and Shape: Neat

Molecular weight: 862.06

Ref: TR-D232500

Deoxy-bigCHAP

CAS: 86303-23-3

Deoxy-bigCHAP is an inhibitor of polyclonal antibodies that are used in immunoassays that measure the concentration of proteins. It is a competitive inhibitor of ester linkages and has been shown to inhibit the growth of Pseudomonas aeruginosa, which is associated with severe respiratory infections. Deoxy-bigCHAP has also been shown to affect biochemical properties such as carbon source utilization and enzyme activity. It is a non-toxic, reversible inhibitor that can be easily removed by enzymatic hydrolysis or chemical cleavage with strong acids or base. The type strain for this compound is S. tuberosum, while the plant species from which it was isolated is Solanum tuberosum (potato).

Formula: C₄₂H₇₅N₃O₁₅

Purity: Min. 95%

Molecular weight: 862.06 g/mol

Ref: 3D-FD21057

Deoxy Big CHAPS extrapure, 95%

CAS: 86303-23-3

Formula: C₄₂H₇₅N₃O₁₅

Molecular weight: 862.06

Ref: SR-40133