CAS 86303-25-5

2'-deoxy-5-[(1E)-3-{[6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoyl]amino}prop-1-en-1-yl]uridine 5'-(tetrahydrogen triphosphate)

Description:

2'-Deoxy-5-[(1E)-3-{[6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoyl]amino}prop-1-en-1-yl]uridine 5'-(tetrahydrogen triphosphate), commonly referred to by its CAS number 86303-25-5, is a complex nucleotide analog. This compound features a deoxyribonucleoside structure, which is characterized by the absence of a hydroxyl group at the 2' position of the ribose sugar, making it distinct from ribonucleotides. The presence of a triphosphate group at the 5' position indicates its potential role in energy transfer and signaling within biological systems. The intricate side chains and modifications, including thieno[3,4-d]imidazole and various acyl groups, suggest that this molecule may exhibit unique biochemical properties, potentially influencing its interactions with enzymes or nucleic acids. Such modifications can enhance stability, specificity, or bioactivity, making it a subject of interest in medicinal chemistry and biochemistry. Overall, this compound exemplifies the complexity and diversity of nucleotide analogs used in research and therapeutic applications.

Formula: C₂₈H₄₅N₆O₁₇P₃S

InChI: InChI=1/C28H45N6O17P3S/c35-19-13-24(49-20(19)15-48-53(44,45)51-54(46,47)50-52(41,42)43)34-14-17(26(38)33-28(34)40)7-6-12-30-22(36)9-2-1-5-11-29-23(37)10-4-3-8-21-25-18(16-55-21)31-27(39)32-25/h6-7,14,18-21,24-25,35H,1-5,8-13,15-16H2,(H,29,37)(H,30,36)(H,44,45)(H,46,47)(H2,31,32,39)(H,33,38,40)(H2,41,42,43)/b7-6+/t18-,19-,20+,21-,24+,25-/m0/s1

Synonyms:

• Biotin-11-deoxyuridine-5'-triphosphate, triethylammonium salt -
• Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5-[(1E)-3-[[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]amino]-1-propen-1-yl]-
• Biotin-11-dUTP *1 mM in Tris Buffer (pH 7.5)*
• Biotin-18-dUTP

Biotin-11-dUTP

CAS: 86303-25-5

Biotin-11-dUTP is a fluorescent substitute for dTTP.

Formula: C₂₈H₄₅N₆O₁₇P₃S

Color and Shape: Solid

Molecular weight: 862.67

Ref: TM-T40969

Biotin-11-deoxyuridine-5'-triphosphate, triethylammonium salt - 1 mM aqueous solution

CAS: 86303-25-5

Biotin-11-deoxyuridine-5'-triphosphate, triethylammonium salt (Biotin-11-dUTP) is a nucleotide analog that is used as a fluorescent substrate for detection of DNA. It is nonradioactive and can be detected in aqueous solution. Biotin-11-dUTP binds to the 3' end of a DNA strand and becomes incorporated into the newly synthesized DNA strand during DNA replication. The incorporation of Biotin-11-dUTP into the newly synthesized strand causes an increase in fluorescence intensity, which can be detected by chemiluminescence. This nucleotide analog has been shown to have high sensitivity for detecting low levels of dsDNA in diploid cells and can be used for detection of bacterial strain, such as Salmonella enterica serovar Typhimurium.

Formula: C₃₄H₅₆N₇O₁₈P₃S

Purity: Min. 95%

Molecular weight: 975.83 g/mol

Ref: 3D-NB32059