CAS 86303-26-6

Biotin-16-deoxyuridine-5'-triphosphate, lithium salt - 1 mM aqueous solution

Description:

Biotin-16-deoxyuridine-5'-triphosphate, lithium salt, is a nucleotide analog that serves as a substrate in various biochemical applications, particularly in molecular biology and biochemistry. This compound is characterized by its incorporation of biotin, a vitamin that plays a crucial role in cellular metabolism, which allows for easy detection and purification of biomolecules. The "16-deoxy" modification indicates the absence of a hydroxyl group at the 16th position of the uridine base, enhancing its stability and specificity in enzymatic reactions. As a triphosphate, it contains three phosphate groups, which are essential for energy transfer and the activation of nucleotides during DNA synthesis. The lithium salt form enhances its solubility in aqueous solutions, making it suitable for laboratory use. Typically, it is utilized in applications such as DNA labeling, amplification, and in assays that require the incorporation of modified nucleotides. Overall, this compound is a valuable tool in genetic research and biotechnological applications due to its unique properties and functionalities.

Formula: C₃₂H₅₂N₇O₁₈P₃S

Synonyms:

• Biotin-16-deoxyuridine-5'-triphosphate
• Biotin-16-deoxyuridine-5'-triphosphate, lithium salt - 1 mM aqueous solution
• Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5-[(1E)-3-[[6-[[4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxobutyl]amino]-1-oxohexyl]amino]-1-propen-1-yl]-
• Biotin-16-dUTP (Biotin-16-deoxyuridine-5'-triphosphate)

Biotin-16-dUTP

CAS: 86303-26-6

Biotin-16-dUTP is a fluorescent substitute of dTTP.

Formula: C₃₂H₅₂N₇O₁₈P₃S

Color and Shape: Solid

Molecular weight: 947.78

Ref: TM-T40970

Biotin-16-deoxyuridine-5'-triphosphate, lithium salt - 1 mM aqueous solution

CAS: 86303-26-6

Biotin-16-deoxyuridine-5'-triphosphate, lithium salt (Biotin-16-dUTP) is a nucleotide analog that is used in the detection of RNA and DNA. It is incorporated into the growing DNA or RNA strand by DNA polymerase and then detected by an enzyme that can detect biotin. Biotin-16-dUTP has been shown to be effective in identifying the occipital cortex during basic protein localization studies. The use of biotin-16-dUTP has also been shown to increase immune response as well as neuronal death in vivo models. This drug has also been shown to cause necrotic cell death in hl-60 cells, which may be due to its ability to inhibit creatine kinase and interfere with cellular ATP production. Biotin-16-dUTP has also been used for the detection of genome dna from HLA class I genes with monoclonal antibodies

Formula: C₃₂H₅₂N₇O₁₈P₃S·xLi

Purity: Min. 95%

Color and Shape: Colourless liquid.

Molecular weight: 947.78 g/mol

Ref: 3D-NB32058