CAS 863031-21-4: Azilsartan medoxomil
Description:Azilsartan medoxomil is an angiotensin II receptor antagonist used primarily in the treatment of hypertension. It is a prodrug that is converted in the body to its active form, azilsartan, which selectively blocks the angiotensin II type 1 receptor, leading to vasodilation and reduced blood pressure. The chemical formula of azilsartan medoxomil reflects its complex structure, which includes a biphenyl group and a carboxylic acid moiety. This compound is characterized by its high potency and long duration of action, making it effective for once-daily dosing. Azilsartan medoxomil is typically administered orally and is well-absorbed, with its pharmacokinetics influenced by factors such as food intake. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. As with other antihypertensive agents, it is important to monitor renal function and electrolyte levels during treatment. Overall, azilsartan medoxomil represents a significant advancement in the management of high blood pressure, providing an effective option for patients requiring antihypertensive therapy.
Formula:C30H24N4O8
InChI:InChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
InChI key:InChIKey=QJFSABGVXDWMIW-UHFFFAOYSA-N
SMILES:O=C1OC(=C(O1)COC(=O)C2=CC=CC=3N=C(OCC)N(C32)CC=4C=CC(=CC4)C=5C=CC=CC5C6=NOC(=O)N6)C
- Synonyms:
- (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-[[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
- (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
- 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
- 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
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- Ipreziv
- Tak 491
- Azilsartan medoxomil