CAS 863031-21-4

Azilsartan medoxomil

Description:

Azilsartan medoxomil is an angiotensin II receptor antagonist used primarily in the treatment of hypertension. It is a prodrug that is converted in the body to its active form, azilsartan, which selectively blocks the angiotensin II type 1 receptor, leading to vasodilation and reduced blood pressure. The chemical formula of azilsartan medoxomil reflects its complex structure, which includes a biphenyl group and a carboxylic acid moiety. This compound is characterized by its high potency and long duration of action, making it effective for once-daily dosing. Azilsartan medoxomil is typically administered orally and is well-absorbed, with its pharmacokinetics influenced by factors such as food intake. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. As with other antihypertensive agents, it is important to monitor renal function and electrolyte levels during treatment. Overall, azilsartan medoxomil represents a significant advancement in the management of high blood pressure, providing an effective option for patients requiring antihypertensive therapy.

Formula: C₃₀H₂₄N₄O₈

InChI: InChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)

InChI key: InChIKey=QJFSABGVXDWMIW-UHFFFAOYSA-N

SMILES: C(N1C=2C(N=C1OCC)=CC=CC2C(OCC=3OC(=O)OC3C)=O)C4=CC=C(C=C4)C5=C(C=CC=C5)C=6NC(=O)ON6

Synonyms:

• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-[[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• Edarbi
• Ipreziv
• Tak 491
• Azilsartan medoxomil

Azilsartan Medoxomil

CAS: 863031-21-4

Formula: C₃₀H₂₄N₄O₈

Color and Shape: White To Off-White Solid

Molecular weight: 568.54

Ref: 4Z-A-8455

(5-Methyl-2-Oxo-1,3-Dioxol-4-Yl)Methyl 2-Ethoxy-1-((2'-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1H-Benzo[D]Imidazole-7-Carboxylate

CAS: 863031-21-4

(5-Methyl-2-Oxo-1,3-Dioxol-4-Yl)Methyl 2-Ethoxy-1-((2'-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1H-Benzo[D]Imidazole-7-Carboxylate

Purity: 98%

Molecular weight: 568.53g/mol

Ref: 54-OR1029032

Azilsartan Medoxomil

CAS: 863031-21-4

Azilsartan Medoxomil

Purity: ≥95%

Molecular weight: 568.53g/mol

Ref: 54-BUP12563

Azilsartan medoxomil

CAS: 863031-21-4

Formula: C₃₀H₂₄N₄O₈

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 568.53

Ref: 7W-GX5951

Azilsartan Medoxomil

CAS: 863031-21-4

Azilsartan Medoxomil (TAK-491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults

Formula: C₃₀H₂₄N₄O₈

Purity: 99.83%

Color and Shape: Solid

Molecular weight: 568.53

Ref: TM-T6219

Azilsartan Medoxomil

Controlled Product

CAS: 863031-21-4

Applications Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)

Formula: C₃₀H₂₄N₄O₈

Color and Shape: Neat

Molecular weight: 568.53

Ref: TR-A926910

Azilsartan Medoxomil-D5

Controlled Product

CAS: 863031-21-4

Formula: C₃₀D₅H₁₉N₄O₈

Color and Shape: Neat

Molecular weight: 573.564

Ref: TR-A926912

Azilsartan medoxomil

CAS: 863031-21-4

Azilsartan medoxomil is an antihypertensive drug, which is a prodrug of the angiotensin II receptor blocker azilsartan. It is synthesized through a chemical process involving the modification of the medoxomil ester, converting it into its active form upon absorption in the gastrointestinal tract. The primary mode of action of azilsartan medoxomil involves selective antagonism of the angiotensin II type 1 (AT1) receptor. By blocking the effects of angiotensin II—a potent vasoconstrictor—azilsartan medoxomil effectively reduces vascular resistance, leading to decreased blood pressure.

Formula: C₃₀H₂₄N₄O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 568.53 g/mol

Ref: 3D-FD15814

Azilsartan Medoxomil

CAS: 863031-21-4

Formula: C₃₀H₂₄N₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 568.5336

Ref: IN-DA00GR8R