CAS 863127-77-9

Dasatinib monohydrate

Description:

Dasatinib monohydrate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of leukemia, particularly chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is characterized by its ability to inhibit multiple tyrosine kinases, including BCR-ABL and SRC family kinases, which play crucial roles in cancer cell proliferation and survival. The monohydrate form indicates that each molecule of dasatinib is associated with one molecule of water, which can influence its solubility and stability. Dasatinib is typically administered orally and is known for its relatively rapid absorption and bioavailability. In terms of physical properties, dasatinib monohydrate is a white to off-white crystalline powder, and it is soluble in organic solvents like dimethyl sulfoxide (DMSO) and slightly soluble in water. Its chemical formula reflects the presence of various functional groups that contribute to its pharmacological activity. As with many pharmaceuticals, dasatinib monohydrate is subject to specific storage conditions to maintain its efficacy and shelf life.

Formula: C₂₂H₂₈ClN₇O₃S

InChI: InChI=1/C22H27N7O2S2.H2O/c1-14-4-3-5-16(32)20(14)27-21(31)17-13-23-22(33-17)26-18-12-19(25-15(2)24-18)29-8-6-28(7-9-29)10-11-30;/h3-5,12-13,30,32H,6-11H2,1-2H3,(H,27,31)(H,23,24,25,26);1H2

InChI key: InChIKey=XHXFZZNHDVTMLI-UHFFFAOYSA-N

SMILES: N(C1=CC(N2CCN(CCO)CC2)=NC(C)=N1)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3.O

Synonyms:

• 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide hydrate (1:1)
• 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1)
• 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, monohydrate
• Bms 35482503
• Dasatinib hydrate
• N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate
• Dasatinib monohydrate
• n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
• DASATINIB
• Dasatinib(TINIBS)

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1)

CAS: 863127-77-9

Formula: C₂₂H₂₈ClN₇O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 506.0208

Ref: IN-DA003277

Dasatinib monohydrate

CAS: 863127-77-9

Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.

Formula: C₂₂H₂₈ClN₇O₃S

Purity: 99.68% - >99.99%

Color and Shape: Solid

Molecular weight: 506.03

Ref: TM-T1448L

Dasatinib

CAS: 863127-77-9

Formula: C₂₂H₂₆ClN₇O₂SH₂O

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 506.02

Ref: 7W-GP0668

Dasatinib monohydrate

CAS: 863127-77-9

Dasatinib monohydrate

Purity: ≥98%

Molecular weight: 506.03g/mol

Ref: 54-BUP14903

Dasatinib Monohydrate

CAS: 863127-77-9

Color and Shape: Neat

Ref: 86-MM3451.00

Dasatinib monohydrate

Controlled Product

CAS: 863127-77-9

Formula: C₂₂H₂₆ClN₇O₂S·H₂O

Color and Shape: White To Off-White

Molecular weight: 506.02

Ref: TR-D193638

Dasatinib Monohydrate

CAS: 863127-77-9

Formula: C₂₂H₂₆ClN₇O₂SH₂O

Molecular weight: 488 : 18.0

Ref: ST-EA-CP-D1008

Dasatinib monohydrate

CAS: 863127-77-9

Inhibits SRC-family of tyrosine kinases

Formula: C₂₂H₂₆ClN₇O₂S·H₂O

Purity: Min. 98 Area-%

Color and Shape: White Yellow Powder

Molecular weight: 506.02 g/mol

Ref: 3D-FD10821

Dasatinib monohydrate - Bio-X ™

CAS: 863127-77-9

Dasatinib is a potent inhibitor of tyrosine kinases and is used in the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors, and other types of cancer. It also inhibits many SRC- family kinases. Dasatinib has been shown to inhibit the proliferation of cancer cells, leading to cell lysis. Additionally, it has anti-angiogenic effects in vivo, inhibiting the development of new blood vessels in solid tumours.

Formula: C₂₂H₂₆ClN₇O₂S•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 506.02 g/mol

Ref: 3D-BD164354

Dasatinib

CAS: 863127-77-9

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₂₂H₂₆ClN₇O₂S·H₂O

Molecular weight: 505.16629

Ref: 45-1164234