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CAS 863329-65-1

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Uridine, 2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-dibenzoate, (2′R)-

Description:
Uridine, 2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-dibenzoate, (2′R)-, is a modified nucleoside that features several unique structural characteristics. This compound is a derivative of uridine, where the 2′-hydroxyl group is replaced with a fluorine atom and a methyl group, enhancing its stability and potentially altering its biological activity. The presence of the dibenzoate moiety indicates that the molecule has two benzoate groups esterified at the 3′ and 5′ positions, which can influence its solubility and interaction with biological targets. The (2′R) designation refers to the specific stereochemistry at the 2′ position, which is crucial for its biological function and recognition by nucleic acid polymerases. Such modifications can affect the compound's pharmacokinetics and therapeutic potential, making it of interest in medicinal chemistry and drug development, particularly in the context of antiviral or anticancer therapies. Overall, this compound exemplifies the intricate relationship between molecular structure and biological function in nucleoside analogs.
Formula:C24H21FN2O7
InChI:InChI=1S/C24H21FN2O7/c1-24(25)19(34-21(30)16-10-6-3-7-11-16)17(14-32-20(29)15-8-4-2-5-9-15)33-22(24)27-13-12-18(28)26-23(27)31/h2-13,17,19,22H,14H2,1H3,(H,26,28,31)/t17-,19-,22-,24-/m1/s1
InChI key:InChIKey=OUDQYAYIRAUNLO-PDKZGUECSA-N
SMILES:C[C@]1(F)[C@@H](O[C@H](COC(=O)C2=CC=CC=C2)[C@H]1OC(=O)C3=CC=CC=C3)N4C(=O)NC(=O)C=C4
Synonyms:
  • (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate
  • (2′R)-2′-Deoxy-2′-fluoro-2′-Methyl-uridine 3′,5′-dibenzoate
  • Sofosbuvir N-2
  • Uridine, 2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-dibenzoate, (2′R)-
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