CAS 86347-14-0

Medetomidine

Description:

Medetomidine is a selective alpha-2 adrenergic agonist primarily used in veterinary medicine as a sedative and analgesic agent. It is characterized by its ability to induce sedation, muscle relaxation, and analgesia, making it particularly useful in procedures requiring anesthesia in animals. Medetomidine acts by binding to alpha-2 adrenergic receptors in the central nervous system, leading to decreased norepinephrine release and resulting in sedation and pain relief. The substance is typically administered via injection and has a rapid onset of action. Its pharmacokinetics include a relatively short half-life, necessitating careful monitoring and potential use of reversal agents, such as atipamezole, to counteract its effects when necessary. Medetomidine is also known for its cardiovascular effects, which can include bradycardia and hypotension, requiring caution in animals with pre-existing health conditions. Overall, medetomidine is a valuable tool in veterinary anesthesia, providing effective sedation and analgesia while requiring careful management to mitigate potential side effects.

Formula: C₁₃H₁₆N₂

InChI: InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)

InChI key: InChIKey=CUHVIMMYOGQXCV-UHFFFAOYSA-N

SMILES: C(C)(C1=C(C)C(C)=CC=C1)C2=CN=CN2

Synonyms:

• ( -)-4-(alpha,2,3-Trimethylbenzyl)imidazole
• (RS)-4-(alpha,2,3-Trimethylbenzyl)imidazol
• 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-
• 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-
• 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
• Medetomidina
• Medetomidina [Spanish]
• Medetomidinum
• Medetomidinum [Latin]
• Selektope
• Slectope
• Unii-Mr15E85Mqm
• dl-Medetomidine

Medetomidine

CAS: 86347-14-0

Formula: C₁₃H₁₆N₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 200.2795

Ref: IN-DA00GRO4

Medetomidine

CAS: 86347-14-0

Medetomidine

Purity: ≥98%

Molecular weight: 200.28g/mol

Ref: 54-BUP20911

Medetomidine

CAS: 86347-14-0

Medetomidine

Purity: ≥95%

Molecular weight: 200.28g/mol

Ref: 54-OR1032000

Medetomidine-d5 (d5-Major)

Controlled Product

CAS: 86347-14-0

Applications Medetomidine-d5 (d5-Major) is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.
References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)

Formula: C₁₃D₅H₁₁N₂

Color and Shape: Neat

Molecular weight: 205.31

Ref: TR-M203257

Medetomidine

CAS: 86347-14-0

Medetomidine (MPV785 free base) is a selective α2-adrenoceptor agonist, with sedative and analgesic and vasoconstrictive hypoxic , in small animal anesthesia.

Formula: C₁₃H₁₆N₂

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 200.28

Ref: TM-T21492

Medetomidine

CAS: 86347-14-0

Purity: 98%

Molecular weight: 200.29

Ref: 10-F787560

Medetomidine-d4

Controlled Product

CAS: 86347-14-0

Formula: C₁₃D₄H₁₂N₂

Color and Shape: Neat

Molecular weight: 204.304

Ref: TR-M203256

Medetomidine

Controlled Product

CAS: 86347-14-0

Medetomidine is an experimental drug that belongs to the group of solubility data. It is a highly selective α-2 adrenergic agonist that has been used in experimental studies to study the central and peripheral effects of the drug. Medetomidine has been shown to induce natriuretic peptide levels and intracellular calcium levels in anesthetized animals. This drug also affects locomotor activity and enzyme activities, which may be due to its ability to increase corticosterone levels. The dexmedetomidine-medetomidine combination was found to produce sedation with minimal cardiovascular effects. The model system used for this study consisted of sedated rats receiving a single intravenous injection of medetomidine or dexmedetomidine alone or in combination with medetomidine. Medetomidine is soluble in water and methanol, but insoluble in ethanol and ether.

Formula: C₁₃H₁₆N₂

Purity: Min. 95%

Molecular weight: 200.28 g/mol

Ref: 3D-FM45840