CAS 863513-91-1

Cebranopadol

Description:

Cebranopadol is a synthetic compound classified as a novel analgesic, primarily acting as a nociceptin/orphanin FQ peptide (NOP) receptor agonist and a μ-opioid receptor agonist. Its dual mechanism of action positions it as a potential alternative to traditional opioids for pain management, particularly in chronic pain conditions. Cebranopadol has been studied for its efficacy in providing analgesia while potentially minimizing the risk of opioid-related side effects, such as respiratory depression and addiction. The compound exhibits a favorable pharmacokinetic profile, with a long half-life that may allow for less frequent dosing. Additionally, its chemical structure includes features typical of opioid analgesics, contributing to its interaction with the central nervous system. Research into cebranopadol is ongoing, focusing on its safety, efficacy, and potential therapeutic applications in various pain syndromes. As with any investigational drug, understanding its full profile, including side effects and long-term impacts, is crucial for its future use in clinical settings.

Formula: C₂₄H₂₇FN₂O

InChI: InChI=1/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3/t23-,24-

InChI key: InChIKey=CSMVOZKEWSOFER-RQNOJGIXNA-N

SMILES: N(C)(C)[C@@]1(CC[C@]2(C3=C(C=4C(N3)=CC=C(F)C4)CCO2)CC1)C5=CC=CC=C5

Synonyms:

• Spiro[cyclohexane-1,1′(3′H)-pyrano[3,4-b]indol]-4-amine, 6′-fluoro-4′,9′-dihydro-N,N-dimethyl-4-phenyl-, trans-
• GRT 6005
• Cebranopadol
• Spiro[cyclohexane-1,1′(3′H)-pyrano[3,4-b]indol]-4-amine, 6′-fluoro-4′,9′-dihydro-N,N-dimethyl-4-phenyl-, (1α,4β)-
• (1α,4β)-6′-Fluoro-4′,9′-dihydro-N,N-dimethyl-4-phenylspiro[cyclohexane-1,1′(3′H)-pyrano[3,4-b]indol]-4-amine
• Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine, 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-, trans-
• CS-1065
• GRT-6005; GRT 6005; GRT6005
• (1r,4r)-6'-Fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine
• spiro[cyclohexane-1,1'(3'h)-pyrano[3,4-b]indol]-4-amine, 6'-fluoro-4',9'-dihydro-n,n-dimethyl-4-phenyl-, (1a,4β)-
• GRT6005
• Cebranopadol(GRT-6005)
• 6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine

Cebranopadol

CAS: 863513-91-1

Cebranopadol

Purity: ≥98%

Molecular weight: 378.48g/mol

Ref: 54-BUP15373

Cebranopadol

CAS: 863513-91-1

Formula: C₂₄H₂₇FN₂O

Molecular weight: 378.48

Ref: 4Z-C-471001

Cebranopadol

Controlled Product

CAS: 863513-91-1

Applications Cebranopadol can be obtained from 1,4-Cyclohexanedione Monoethylene Acetal (C987955) which is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal (C987955) is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.
References Linders, J. et al.: J. Lab. Comp. Radiopharm., 31, 671 (1992); Lednicer, D. et al.: J. Med. Chem., 22, 1157 (1979);

Formula: C₂₄H₂₇FN₂O

Color and Shape: Neat

Molecular weight: 378.48

Ref: TR-C228810

GRT6005

CAS: 863513-91-1

Formula: C₂₄H₂₇FN₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 378.4824

Ref: IN-DA00GU2F

Cebranopadol

CAS: 863513-91-1

Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP)

Formula: C₂₄H₂₇FN₂O

Purity: 98.32% - 99.78%

Color and Shape: Solid

Molecular weight: 378.48

Ref: TM-T5167