CAS 863918-55-2

5H-Pyrano[3,2-d]thiazole-6,7-diol, 3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-2-propyl-, (3aR,5R,6S,7R,7aR)-

Description:

5H-Pyrano[3,2-d]thiazole-6,7-diol, 3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-2-propyl-, with CAS number 863918-55-2, is a complex organic compound characterized by its unique bicyclic structure that incorporates both a pyran and thiazole moiety. This compound features multiple functional groups, including hydroxymethyl and diol functionalities, which contribute to its potential reactivity and solubility in various solvents. The stereochemistry indicated by the (3aR,5R,6S,7R,7aR) designation suggests specific spatial arrangements of its atoms, which can influence its biological activity and interactions with other molecules. Such compounds may exhibit interesting pharmacological properties, making them of interest in medicinal chemistry. The presence of the propyl group enhances its hydrophobic characteristics, potentially affecting its bioavailability and interaction with biological membranes. Overall, this compound's structural complexity and functional diversity suggest potential applications in drug development and other fields of chemical research.

Formula: C₁₀H₁₇NO₄S

Synonyms:

• 5H-Pyrano[3,2-d]thiazole-6,7-diol, 3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-2-propyl-, (3aR,5R,6S,7R,7aR)-

NButGT - Bio-X ™

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.  Linagliptin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₇NO₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 247.31 g/mol

Ref: 3D-BN300156

NButGT

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.

Formula: C₁₀H₁₇NO₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 247.31 g/mol

Ref: 3D-NN180123