CAS 86401-95-8

Methylprednisolone aceponate

Description:

Methylprednisolone aceponate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is primarily used in dermatology for the treatment of various skin conditions, including eczema and psoriasis. The compound is characterized by its ability to reduce inflammation and modulate immune responses, making it effective in managing allergic reactions and autoimmune disorders. Methylprednisolone aceponate is typically formulated as a topical preparation, allowing for localized treatment with minimal systemic absorption. Its chemical structure includes a methylprednisolone backbone modified with an aceponate ester, which enhances its skin penetration and potency. The substance is generally well-tolerated, but like other corticosteroids, it may cause side effects such as skin thinning or irritation with prolonged use. Due to its efficacy and favorable pharmacokinetic profile, methylprednisolone aceponate is a valuable option in the therapeutic arsenal for inflammatory skin diseases.

Formula: C₂₇H₃₆O₇

InChI: InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1

InChI key: InChIKey=DALKLAYLIPSCQL-YPYQNWSCSA-N

SMILES: C(COC(C)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C([C@@H](C)C3)=CC(=O)C=C4)[H])[H])[H]

Synonyms:

• (6Alpha,11Beta)-21-(Acetyloxy)-11-Hydroxy-6-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
• (6a,11b)-21-(Acetyloxy)-11-hydroxy-6-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
• (6a,11b)-21-(Acetyloxy)-11-hydroxy-6-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate
• (6alpha,11beta)-21-Acetoxy-11-hydroxy-6-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate
• 11b,17,21-Trihydroxy-6a-methylpregna-1,4-diene-3,20-dione 21-Acetate 17-Propionate
• Advantan
• Comfoderm K
• Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-11-Hydroxy-6-Methyl-17-(1-Oxopropoxy)-, (6Alpha,11Beta)-
• Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11-hydroxy-6-methyl-17-(1-oxopropoxy)-, (6α,11β)-
• Zk 91588
• Methylprednisolone aceponate

Methylprednisolone aceponate

CAS: 86401-95-8

Formula: C₂₇H₃₆O₇

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 472.57

Ref: 7W-GP4034

Methylprednisolone Aceponate

CAS: 86401-95-8

Methylprednisolone Aceponate

Purity: ≥98%

Molecular weight: 472.57g/mol

Ref: 54-BUP10924

6-α-Methyl Prednisolone Aceponate

CAS: 86401-95-8

Formula: C₂₇H₃₆O₇

Color and Shape: White To Off-White Solid

Molecular weight: 472.58

Ref: 4Z-P-11105

METHYLPREDNISOLONE ACEPONATE

CAS: 86401-95-8

Purity: 95%

Molecular weight: 472.578002929688

Ref: 10-F800506

6α-Methyl Prednisolone Aceponate

CAS: 86401-95-8

Applications Used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.
References Miyachi, Y., et al.: Br. J. Dermatol., 114, 231 (1986), Rallis, E., et al.: Drugs Exp. Clin. Res., 30, 191 (2004), Ozcan, H., et al.: Eur. J. Dermatol., 17, 313 (2007),

Formula: C₂₇H₃₆O₇

Color and Shape: White To Off-White

Molecular weight: 472.57

Ref: TR-M325725

Methylprednisolone aceponate

CAS: 86401-95-8

Formula: C₂₇H₃₆O₇

Molecular weight: 472.57

Ref: ST-EA-CP-M14013

Methylprednisolone Aceponate

CAS: 86401-95-8

Methylprednisolone Aceponate (SH 440), a non-halogenated corticosteroid, is a potent anti-inflammatory agent.

Formula: C₂₇H₃₆O₇

Purity: 99.00% - 99.61%

Color and Shape: Solid

Molecular weight: 472.57

Ref: TM-T1171L

6α-Methyl prednisolone aceponate

Controlled Product

CAS: 86401-95-8

6a-Methyl prednisolone aceponate is a prodrug of prednisolone that inhibits the activity of certain enzymes in skin cells. This inhibition prevents the release of inflammatory cytokines, which are responsible for the symptoms of inflammatory diseases. 6a-Methyl prednisolone aceponate has been shown to provide long-term efficacy for patients with chronic inflammatory skin disorders such as psoriasis and atopic dermatitis.

Formula: C₂₇H₃₆O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 472.57 g/mol

Ref: 3D-FM25550