CAS 864249-60-5

AMG-548

CAS: 864249-60-5

AMG-548

Purity: ≥98%

Molecular weight: 461.56g/mol

Ref: 54-BUP22212

AMG 548

Controlled Product

CAS: 864249-60-5

Formula: C₂₉H₂₇N₅O

Color and Shape: Neat

Molecular weight: 461.558

Ref: TR-A614420

AMG 548

CAS: 864249-60-5

AMG 548 is a small molecule that binds to the β-catenin protein in the cytoplasm. This binding prevents the formation of covalent linkages between β-catenin and other proteins, thereby inhibiting its role in signal transduction. AMG 548 has been shown to be effective against inflammatory bowel disease in rats and may also have potential for treating autoimmune diseases such as arthritis. AMG 548 is metabolized by peptidases in the gut, liver, and kidney and has a high clearance rate. The pharmacokinetic properties of this drug are not yet known.

Formula: C₂₉H₂₇N₅O

Purity: Min. 95%

Molecular weight: 461.56 g/mol

Ref: 3D-PJB24960

AMG-548

CAS: 864249-60-5

AMG-548, oral p38α inhibitor (Ki=0.5 nM), >1000x selectivity over p38γ/δ, blocks TNFα (IC50=3 nM), also inhibits Wnt/Casein kinase 1δ/ε.

Formula: C₂₉H₂₇N₅O

Purity: 99.91%

Color and Shape: Solid

Molecular weight: 461.56

Ref: TM-T10298L