CAS 864825-13-8

Eluxadoline Dihydrochloride

Description:

Eluxadoline dihydrochloride is a synthetic compound primarily used in the treatment of irritable bowel syndrome with diarrhea (IBS-D). It functions as a mixed opioid receptor agonist and antagonist, specifically targeting the mu-opioid and delta-opioid receptors, which helps to modulate gastrointestinal motility and reduce abdominal pain. The substance is characterized by its dihydrochloride salt form, enhancing its solubility and stability in pharmaceutical formulations. Eluxadoline is typically administered orally and is known for its pharmacokinetic properties, including a relatively short half-life and metabolism primarily through the liver. Common side effects may include nausea, constipation, and abdominal pain, reflecting its action on the gastrointestinal system. Due to its mechanism of action, it is contraindicated in patients with a history of pancreatitis or severe liver impairment. Overall, eluxadoline dihydrochloride represents a targeted therapeutic approach for managing IBS-D, balancing efficacy with a need for careful patient selection and monitoring.

Eluxadoline-d3 Dihydrochloride

Controlled Product

CAS: 864825-13-8

Formula: C₃₂H₃₄D₃Cl₂N₅O₅

Color and Shape: Neat

Molecular weight: 572.669

Ref: TR-E508202

Eluxadoline-13C,d3 Dihydrochloride

Controlled Product

CAS: 864821-90-9, 864825-13-8

Applications Eluxadoline-13C,d3 Dihydrochloride is labelled Eluxadoline Dihydrochloride (E508200) which is a mixed μ opioid receptor agonist / δ opioid receptor antagonist used in the treatment and modulation of gastrointestinal function. Used in patients with diarrhea-predominant IBS.
References Wade, P. et al.: Brit. J. Pharm., 167, 1111 (2012); Breslin, H. et al.: Bioorg. Med. Chem. Lett., 22, 4869 (2012)

Formula: C₃₁CH₃₄D₃Cl₂N₅O₅

Color and Shape: Neat

Molecular weight: 573.662

Ref: TR-E508203

Eluxadoline Dihydrochloride

Controlled Product

CAS: 864825-13-8

Formula: C₃₂H₃₅N₅O₅·2ClH

Color and Shape: Neat

Molecular weight: 642.573

Ref: TR-E508200

Eluxadoline-d3 dihydrochloride

Controlled Product

CAS: 864825-13-8

Eluxadoline is a δ-opioid receptor agonist that has been shown to have contractile properties and is used as a pharmaceutical treatment for bowel disease. Eluxadoline is an analog of the endogenous fatty acid, eluxadoline, which consists of two aliphatic chains with the chemical formula C24H36O2. It binds to and activates δ-opioid receptors in the gastrointestinal tract, thereby inhibiting intestinal motility and reducing abdominal pain. The drug also has a therapeutic effect on symptoms of irritable bowel syndrome (IBS). Eluxadoline acts as an antagonist at other opioid receptors in the body. The drug's effects are dose-dependent, meaning that higher doses will result in greater efficacy. Eluxadoline has not been shown to be effective against organic acids or diagnostic agents that cause diarrhea.

Formula: C₃₂H₃₇Cl₂N₅O₅

Purity: Min. 95%

Molecular weight: 642.6 g/mol

Ref: 3D-PJB82513