CAS 865-21-4

Vinblastine

Description:

Vinblastine is a potent alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily known for its application in cancer chemotherapy, particularly in the treatment of various types of leukemia and lymphomas. The compound functions by inhibiting microtubule formation during cell division, effectively disrupting the mitotic spindle and preventing cancer cells from proliferating. Vinblastine is characterized by its complex structure, which includes a dimeric indole alkaloid framework. It is typically administered intravenously and has a relatively short half-life in the body, necessitating careful dosing and monitoring for side effects. Common adverse effects include nausea, vomiting, hair loss, and myelosuppression, which can lead to increased susceptibility to infections. Due to its mechanism of action, vinblastine is classified as a mitotic inhibitor and is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Its use is strictly regulated, and it is classified as a hazardous drug, requiring appropriate handling and disposal measures in clinical settings.

Formula: C₄₆H₅₈N₄O₉

InChI: InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

InChI key: InChIKey=JXLYSJRDGCGARV-CFWMRBGOSA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]

Synonyms:

• (+)-Vinblastine
• 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
• 1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, [3aR-[3aα,4β,5β,5aβ,9(3R*,5S*,7R*,9S*),10bR*,13aα]]-
• 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
• Dimethyl(2β,3β,4β,5α,12β,19α)-15-[(5S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3,4-dicarboxylate
• Rozevin
• VLB
• Valban
• Vinblastin
• Vinblastina
• Vincaleucoblastin
• Vincaleucoblastine
• [3aR-[3aα,4β,5β,5aβ,9(3R*,5S*,7R*,9S*),10bR*,13aα]]-Methyl 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino[8,1-cd]carbazole-5-carboxylate

Vinblastine (Vincristine EP Impurity H, Vindesine EP Impurity B)

CAS: 865-21-4

Formula: C₄₆H₅₈N₄O₉

Molecular weight: 810.99

Ref: 4Z-V-2622

Vinblastine

CAS: 865-21-4

Vinblastine

Purity: ≥95%

Molecular weight: 810.97g/mol

Ref: 54-BUP20916

Vinblastine

CAS: 865-21-4

Formula: C₄₆H₅₈N₄O₉

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or crystals

Molecular weight: 810.97

Ref: 7W-GP2901

Vinblastine

CAS: 865-21-4

Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.

Formula: C₄₆H₅₈N₄O₉

Purity: 97.42%

Color and Shape: Powder

Molecular weight: 810.97

Ref: TM-T6721

Vinblastine

CAS: 865-21-4

Formula: C₄₆H₅₈N₄O₉

Purity: 95%~99%

Molecular weight: 810.989

Ref: BP-BP1436

Vinblastine

Controlled Product

CAS: 865-21-4

Vinblastine is an alkaloid that inhibits the activity of microtubules in cells. It has been shown to be active against hyperproliferative diseases, including bowel disease and brain function disorders. Vinblastine binds to the polymerase chain reaction (PCR) enzyme by c-jun phosphorylation and prevents DNA synthesis. Vinblastine also inhibits the activities of enzymes involved in energy metabolism and natural compounds such as model systems and toxicological studies. It has been shown to have antiviral properties against human herpesvirus type 1 (HHV-1). Vinblastine is used to treat certain types of cancer, including acute leukaemia, Hodgkin's lymphoma, Kaposi sarcoma, malignant melanoma, ovarian cancer, and testicular cancer.

Formula: C₄₆H₅₈N₄O₉

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 810.97 g/mol

Ref: 3D-FV73878