CAS 865-21-4: Vinblastine

Description: Vinblastine is a potent alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily known for its application in cancer chemotherapy, particularly in the treatment of various types of leukemia and lymphomas. The compound functions by inhibiting microtubule formation during cell division, effectively disrupting the mitotic spindle and preventing cancer cells from proliferating. Vinblastine is characterized by its complex structure, which includes a dimeric indole alkaloid framework. It is typically administered intravenously and has a relatively short half-life in the body, necessitating careful dosing and monitoring for side effects. Common adverse effects include nausea, vomiting, hair loss, and myelosuppression, which can lead to increased susceptibility to infections. Due to its mechanism of action, vinblastine is classified as a mitotic inhibitor and is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Its use is strictly regulated, and it is classified as a hazardous drug, requiring appropriate handling and disposal measures in clinical settings.

Formula: C₄₆H₅₈N₄O₉

InChI: InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

InChI key: InChIKey=JXLYSJRDGCGARV-CFWMRBGOSA-N

SMILES: O=C(OC1C(O)(C(=O)OC)C2N(C3=CC(OC)=C(C=C3C42CCN5CC=CC1(CC)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CCN9CC(CC(O)(C9)CC)C6)C)C

Synonyms:

• (+)-Vinblastine
• 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
• 1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, [3aR-[3aα,4β,5β,5aβ,9(3R*,5S*,7R*,9S*),10bR*,13aα]]-
• 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
• Dimethyl(2β,3β,4β,5α,12β,19α)-15-[(5S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3,4-dicarboxylate
• Rozevin
• VLB
• Valban
• Vinblastin
• Vinblastina
• Vincaleucoblastin
• Vincaleucoblastine
• [3aR-[3aα,4β,5β,5aβ,9(3R*,5S*,7R*,9S*),10bR*,13aα]]-Methyl 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino[8,1-cd]carbazole-5-carboxylate
• Vincaleukoblastine

Vinblastine

CAS: 865-21-4

• Formula: C₄₆H₅₈N₄O₉
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder or crystals
• Molecular weight: 810.97

Vinblastine

CAS: 865-21-4

Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to …

• Formula: C₄₆H₅₈N₄O₉
• Purity: 97.42%
• Color and Shape: Powder
• Molecular weight: 810.97

Vinblastine

CAS: 865-21-4

• Formula: C₄₆H₅₈N₄O₉
• Purity: 95%~99%
• Molecular weight: 810.989

Vinblastine

CAS: 865-21-4

Please enquire for more information about Vinblastine including the price, delivery time and more detailed …

• Formula: C₄₆H₅₈N₄O₉
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 810.97 g/mol