CAS 865200-20-0
:Giripladib
Description:
Giripladib is a synthetic compound primarily studied for its potential therapeutic applications, particularly in the context of cardiovascular diseases. It functions as a selective inhibitor of the enzyme phospholipase A2, which plays a crucial role in the inflammatory response and the metabolism of phospholipids. By inhibiting this enzyme, Giripladib may help reduce inflammation and tissue damage associated with various pathological conditions. The compound has been evaluated in preclinical and clinical studies for its efficacy in treating conditions such as acute coronary syndrome and other inflammatory disorders. Its chemical structure features specific functional groups that contribute to its biological activity and selectivity. As with many pharmacological agents, the safety profile, pharmacokinetics, and potential side effects are critical areas of investigation to ensure its therapeutic viability. Overall, Giripladib represents a promising avenue in drug development aimed at mitigating inflammation and improving cardiovascular health.
Formula:C41H36ClF3N2O4S
InChI:InChI=1/C41H36ClF3N2O4S/c42-33-22-23-37-35(26-33)34(16-9-10-28-18-20-31(21-19-28)40(48)49)38(47(37)39(29-11-3-1-4-12-29)30-13-5-2-6-14-30)24-25-46-52(50,51)27-32-15-7-8-17-36(32)41(43,44)45/h1-8,11-15,17-23,26,39,46H,9-10,16,24-25,27H2,(H,48,49)
SMILES:c1ccc(cc1)C(c1ccccc1)n1c2ccc(cc2c(CCCc2ccc(cc2)C(=O)O)c1CCNS(=O)(=O)Cc1ccccc1C(F)(F)F)Cl
Synonyms:- 4-(3-[5-Chloro-1-(diphenylmethyl)-2-[2-(((2-(trifluoromethyl)benzyl)sulfonyl)amino)ethyl]-1H-indole-3-yl]propyl)benzoic acid
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Found 3 products.
Giripladib
CAS:<p>Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.</p>Formula:C41H36ClF3N2O4SPurity:99.64%Color and Shape:SolidMolecular weight:745.25
