CAS 865285-47-8

N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide

Description:

N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide is a chemical compound characterized by its complex structure, which includes an oxadiazole ring and a trifluoromethyl group. The presence of the 4-fluorophenyl moiety contributes to its potential biological activity, as fluorinated aromatic compounds often exhibit enhanced lipophilicity and metabolic stability. The oxadiazole ring is known for its role in various pharmacological applications, including antimicrobial and anti-inflammatory properties. The trifluoromethyl group is a notable feature that can influence the compound's electronic properties and reactivity, often enhancing its potency in biological systems. This compound may be of interest in medicinal chemistry and drug development due to its unique structural attributes, which could lead to novel therapeutic agents. Its CAS number, 865285-47-8, allows for easy identification and reference in chemical databases. Overall, the combination of these functional groups suggests potential utility in various chemical and pharmaceutical applications.

Formula: C₁₆H₉F₄N₃O₂

Synonyms:

• Benzamide, N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)-
• KKL-40
• (KKL40)
• N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide

KKL-40

CAS: 865285-47-8

KKL-40 is a small-molecule inhibitor that targets the trans-translation process, effectively suppressing methicillin-sensitive and resistant Staphylococcus aureus (S. aureus) and other Gram-positive pathogens, including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. It works in synergy with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not show synergistic effects with other antibiotics such as daptomycin, kanamycin, or erythromycin. KKL-40 inhibits trans-translation, an extreme form of recoding, while being non-toxic to HeLa cells.

Formula: C₁₆H₉F₄N₃O₂

Color and Shape: Solid

Molecular weight: 351.255

Ref: TM-T205229