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CAS 86541-74-4

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Benazepril hydrochloride

Description:
Benazepril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range of approximately 4.5 to 6.5 in solution. The molecular formula of benazepril hydrochloride is C24H28N2O5·HCl, indicating the presence of a hydrochloride salt, which enhances its solubility and stability. The compound works by inhibiting the ACE enzyme, leading to decreased production of angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. Benazepril is typically administered orally and is often prescribed in combination with other antihypertensive agents for enhanced efficacy. Common side effects may include dizziness, cough, and elevated potassium levels. As with other ACE inhibitors, it is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy and during pregnancy due to potential risks to fetal development.
Formula:C24H28N2O5·ClH
InChI:InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1
InChI key:InChIKey=VPSRQEHTHIMDQM-FKLPMGAJSA-N
SMILES:C(C(O)=O)N1C=2C(CC[C@H](N[C@@H](CCC3=CC=CC=C3)C(OCC)=O)C1=O)=CC=CC2.Cl
Synonyms:
  • 1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, hydrochloride (1:1), (3S)-
  • 1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, (3S)-
  • 1H-1-Benzazepine-1-acetic acid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, monohydrochloride, [S-(R*,R*)]-
  • Benazepril Hydrochloride
  • CGS 14824A HCl
  • Cgs 14824A
  • Lotensin
  • Lotension
  • [(3R)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride (1:1)
  • [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride
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Found 16 products.