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CAS 86541-78-8

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Benazeprilat

Description:
Benazeprilat is an angiotensin-converting enzyme (ACE) inhibitor, primarily used in the treatment of hypertension and heart failure. It is the active metabolite of benazepril, which is administered as a prodrug. Benazeprilat works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby leading to vasodilation and reduced blood pressure. The chemical structure of benazeprilat includes a carboxyl group, which is essential for its activity, and it is characterized by its ability to bind to the ACE enzyme. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Benazeprilat is generally well-tolerated, but like other ACE inhibitors, it may cause side effects such as cough, hyperkalemia, and angioedema in some patients. Its pharmacokinetics can be influenced by factors such as renal function, making monitoring important in certain populations. Overall, benazeprilat is an effective medication for managing cardiovascular conditions.
Formula:C22H24N2O5
InChI:InChI=1/C22H24N2O5/c25-20(26)14-24-19-9-5-4-8-16(19)11-13-17(21(24)27)23-18(22(28)29)12-10-15-6-2-1-3-7-15/h1-9,17-18,23H,10-14H2,(H,25,26)(H,28,29)/t17-,18-/m0/s1
InChI key:InChIKey=MADRIHWFJGRSBP-ROUUACIJSA-N
SMILES:C(C(O)=O)N1C=2C(CC[C@H](N[C@@H](CCC3=CC=CC=C3)C(O)=O)C1=O)=CC=CC2
Synonyms:
  • (2S)-2-{[(3S)-1-(Carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]amino}-4-phenylbutanoic acid
  • (3S)-3-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid
  • (S-(R*,R*))-3-((1-Carboxy-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid
  • 1H-1-Benzazepine-1-acetic acid, 3-[(1-carboxy-3-phenylpropyl)amino]-2,3,4,5-tetrahydro-2-oxo-, [S-(R*,R*)]-
  • 1H-1-benzazepine-1-acetic acid, 3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-
  • Benazeprilate
  • Cgs 14831
  • Benazeprilat
  • 1H-1-Benzazepine-1-acetic acid, 3-(1S)-1-carboxy-3-phenylpropylamino-2,3,4,5-tetrahydro-2-oxo-, (3S)-
  • carboxy-3-phenylpropyl]amino-2,3,4,5-tetrahydro-2-oxo-
  • See more synonyms
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Found 10 products.