CAS 865759-25-7

Trelagliptin

Description:

Trelagliptin is a pharmaceutical compound classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor, primarily used in the management of type 2 diabetes mellitus. It functions by enhancing the levels of incretin hormones, which in turn stimulate insulin secretion in response to meals and inhibit glucagon release, thereby helping to regulate blood glucose levels. Trelagliptin is characterized by its long half-life, allowing for once-weekly dosing, which can improve patient adherence to treatment. The chemical structure of Trelagliptin includes a unique bicyclic moiety that contributes to its potency and selectivity for the DPP-4 enzyme. It is typically administered in oral form and is often used in combination with other antidiabetic agents to achieve better glycemic control. As with other DPP-4 inhibitors, potential side effects may include gastrointestinal disturbances and a risk of pancreatitis. Overall, Trelagliptin represents a significant advancement in diabetes therapy, offering a convenient dosing schedule and effective glycemic management.

Formula: C₁₈H₂₀FN₅O₂

InChI: InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1

InChI key: InChIKey=IWYJYHUNXVAVAA-OAHLLOKOSA-N

SMILES: C(N1C(=CC(=O)N(C)C1=O)N2C[C@H](N)CCC2)C3=C(C#N)C=CC(F)=C3

Synonyms:

• Trelagliptin
• (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile
• 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile
• (R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile
• Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-

Trelagliptin

CAS: 865759-25-7

Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.

Formula: C₁₈H₂₀FN₅O₂

Purity: 98.88%

Color and Shape: Solid

Molecular weight: 357.38

Ref: TM-T6237

Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-

CAS: 865759-25-7

Formula: C₁₈H₂₀FN₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 357.3821

Ref: IN-DA00IE4Q

Trelagliptin

CAS: 865759-25-7

Trelagliptin

Purity: ≥98%

Molecular weight: 357.38g/mol

Ref: 54-BUP10357

TRELAGLIPTIN

CAS: 865759-25-7

Formula: C₁₈H₂₀FN₅O₂

Purity: 98%

Molecular weight: 357.389

Ref: 10-F468424