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CAS 865759-25-7

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Trelagliptin

Description:
Trelagliptin is a pharmaceutical compound classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor, primarily used in the management of type 2 diabetes mellitus. It functions by enhancing the levels of incretin hormones, which in turn stimulate insulin secretion in response to meals and inhibit glucagon release, thereby helping to regulate blood glucose levels. Trelagliptin is characterized by its long half-life, allowing for once-weekly dosing, which can improve patient adherence to treatment. The chemical structure of Trelagliptin includes a unique bicyclic moiety that contributes to its potency and selectivity for the DPP-4 enzyme. It is typically administered in oral form and is often used in combination with other antidiabetic agents to achieve better glycemic control. As with other DPP-4 inhibitors, potential side effects may include gastrointestinal disturbances and a risk of pancreatitis. Overall, Trelagliptin represents a significant advancement in diabetes therapy, offering a convenient dosing schedule and effective glycemic management.
Formula:C18H20FN5O2
InChI:InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChI key:InChIKey=IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES:C(N1C(=CC(=O)N(C)C1=O)N2C[C@H](N)CCC2)C3=C(C#N)C=CC(F)=C3
Synonyms:
  • Trelagliptin
  • (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile
  • 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile
  • (R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile
  • Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-
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Found 4 products.