CAS 865854-05-3
:Tideglusib
Description:
Tideglusib is a small molecule inhibitor primarily known for its role as a glycogen synthase kinase 3 (GSK-3) inhibitor. It has garnered attention in the field of neurodegenerative diseases, particularly Alzheimer's disease, due to its potential to promote neurogenesis and enhance cognitive function. Tideglusib is characterized by its ability to modulate various signaling pathways, which can influence cell survival and differentiation. The compound is typically administered in a pharmaceutical context, and its efficacy and safety profiles have been evaluated in clinical trials. Tideglusib is a white to off-white solid, and its solubility and stability can vary depending on the formulation and conditions. As a research chemical, it is important to handle Tideglusib with care, adhering to safety protocols, as with any bioactive compound. Its mechanism of action and therapeutic potential continue to be subjects of ongoing research, highlighting its significance in the development of treatments for neurodegenerative conditions.
Formula:C19H14N2O2S
InChI:InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChI key:InChIKey=PMJIHLSCWIDGMD-UHFFFAOYSA-N
SMILES:O=C1N(C=2C3=C(C=CC2)C=CC=C3)SC(=O)N1CC4=CC=CC=C4
Synonyms:- Tideglusib
- NP 12
- 2-(1-Naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
- 1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-
- 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
- Destructible
- NP-031112
- NP-12; NP031112; NP 031112; NP-031112
- CS-596
- 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione(Tideglusib)
- NP 031112
- Tideglusib(NP-031112)
- Tideglusib (NP031112, NP-12)
- IUSIB(NP0311120）
- NP031112
- TIDEGLUSIB;NP-12;NP031112
- See more synonyms
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Found 9 products.
Tideglusib
CAS:<p>Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.</p>Formula:C19H14N2O2SPurity:98.40% - 99.35%Color and Shape:SolidMolecular weight:334.39Tideglusib
CAS:<p>An irreversible GSK-3β inhibitor that reduces phosphorylation of tau proteins, protects from neuronal loss and has cognitive and behavioural benefits in murine models. Studied for its potential as a therapeutic agent in Alzheimer’s disease and other neurodegenerative diseases. Tideglusib was also shown to inhibit the main protease Mpro from the SARS-CoV-2 virus with IC50 of 1.55 μM.</p>Formula:C19H14N2O2SPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:334.39 g/molTideglusib (benzyl-d7)
CAS:Controlled Product<p>Applications Tideglusib (benzyl-d7) is deuterium labelled form of Tideglusib (T438700), which is used in the treatment of brain atrophy and movement disorder issues.<br>References Hoeglinger, G. et al.: Movement DIs., 29, 579 (2014); Tolosa, E. et al.: Movement Dis., 29, 570 (2014);<br></p>Formula:C19D7H7N2O2SColor and Shape:NeatMolecular weight:341.435Tideglusib
CAS:Controlled Product<p>Applications Tideglusib is used in the treatment of brain atrophy, and movement disorder issues.<br>References Hoeglinger, G. et al.: Movement DIs., 29, 579 (2014); Tolosa, E. et al.: Movement Dis., 29, 570 (2014);<br></p>Formula:C19H14N2O2SColor and Shape:NeatMolecular weight:334.39Tideglusib (naphthyl-d7)
CAS:Controlled Product<p>Applications Tideglusib (naphthyl-d7) is deuterium labelled form of Tideglusib (T438700), which is used in the treatment of brain atrophy and movement disorder issues.<br>References Hoeglinger, G. et al.: Movement DIs., 29, 579 (2014); Tolosa, E. et al.: Movement Dis., 29, 570 (2014);<br></p>Formula:C19H7D7N2O2SColor and Shape:NeatMolecular weight:341.43
