CAS 866323-14-0

Belinostat

Description:

Belinostat is a synthetic compound classified as a hydroxamic acid and is primarily known for its role as a histone deacetylase (HDAC) inhibitor. It is utilized in the treatment of certain types of cancer, particularly peripheral T-cell lymphoma. The mechanism of action involves the inhibition of HDAC enzymes, which leads to an increase in acetylation of histones and non-histone proteins, ultimately resulting in altered gene expression, cell cycle arrest, and apoptosis in cancer cells. Belinostat is typically administered intravenously and has been studied for its efficacy in combination with other therapeutic agents. Its chemical structure includes a hydroxamic acid functional group, which is crucial for its biological activity. The compound is characterized by its moderate solubility in water and its stability under physiological conditions. As with many anticancer agents, potential side effects may include fatigue, nausea, and hematological toxicities, necessitating careful monitoring during treatment. Overall, Belinostat represents a significant advancement in targeted cancer therapies, particularly for hematological malignancies.

Formula: C₁₅H₁₄N₂O₄S

InChI: InChI=1/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChI key: InChIKey=NCNRHFGMJRPRSK-MDZDMXLPSA-N

SMILES: S(NC1=CC=CC=C1)(=O)(=O)C2=CC(/C=C/C(NO)=O)=CC=C2

Synonyms:

• (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
• 2-propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-, (2E)-
• Beleodaq
• Belinostat
• Px 105684
• Pxd 101
• Pxd101
• Belinostat（E）
• Belista
• PXD101;PX105684;PXD-101;PXD 101;PX-105684

2-Propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-, (2E)-

CAS: 866323-14-0

Formula: C₁₅H₁₄N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 318.3477

Ref: IN-DA004OKJ

Belinostat

CAS: 866323-14-0

Belinostat

Purity: 98%

Molecular weight: 318.35g/mol

Ref: 54-OR1025635

Belinostat

CAS: 866323-14-0

Belinostat

Purity: ≥98%

Molecular weight: 318.35g/mol

Ref: 54-BUP15622

Belinostat

CAS: 866323-14-0

Formula: C₁₅H₁₄N₂O₄S

Color and Shape: Off-White Solid

Molecular weight: 318.35

Ref: 4Z-B-130001

Belinostat

CAS: 866323-14-0

Formula: C₁₅H₁₄N₂O₄S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 318.35

Ref: 3B-B5888

Belinostat

CAS: 866323-14-0

Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.

Formula: C₁₅H₁₄N₂O₄S

Purity: 99.75% - >99.99%

Color and Shape: Solid

Molecular weight: 318.35

Ref: TM-T8517

N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE

CAS: 866323-14-0

Formula: C₁₅H₁₄N₂O₄S

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 318.35

Ref: 10-F053644

Belinostat

CAS: 866323-14-0

Inhibitor of histone deacetylases

Purity: Min. 95%

Ref: 3D-FB76300

[13C6] Belinostat

CAS: 866323-14-0

Please enquire for more information about [13C6] Belinostat including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₉₁₃C₆H₁₄N₂O₄S

Molecular weight: 324.3 g/mol

Ref: 3D-FB76301