CAS 86639-52-3
:7-Ethyl-10-hydroxycamptothecin
Description:
7-Ethyl-10-hydroxycamptothecin, with the CAS number 86639-52-3, is a derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This substance is characterized by its structural modifications, which enhance its pharmacological properties. It exhibits potent antitumor activity, primarily through its mechanism of action as a topoisomerase I inhibitor, disrupting DNA replication and transcription processes in cancer cells. The compound is typically a pale yellow solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) but has limited solubility in water. Its therapeutic potential has been explored in various cancer treatments, particularly for solid tumors. However, like many chemotherapeutic agents, it may exhibit side effects, including toxicity to normal cells. Research continues to optimize its efficacy and minimize adverse effects, making it a subject of interest in medicinal chemistry and oncology.
Formula:C22H20N2O5
InChI:InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChI key:InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES:C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5
Synonyms:- (19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
- (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-Sn 38
- 10-Hydroxy-7-ethylcamptothecin
- 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-
- 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
- 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 7-Ethyl-10-Hydroxy Camptothecin
- 7-Ethyl-10-Hydroxy-Camptothecine
- 7-Ethyl-10-hydroxy-20(S)-camptothecin
- 7-Ethyl-10-hydroxycamptothecine
- Intermediate of Irinotecan 1
- SN 38 (pharmaceutical)
- SN 38 lactone
- Sn-38
- See more synonyms
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Found 14 products.
7-Ethyl-10-hydroxycamptothecin
CAS:Formula:C22H20N2O5Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Green powder to crystalMolecular weight:392.41Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoiFormula:C22H20N2O5Color and Shape:Yellow Off-White PowderMolecular weight:392.137227-Ethyl-10-hydroxycamptothecin
CAS:Formula:C22H20N2O5Purity:≥ 98.0%Color and Shape:Off-white to yellow powderMolecular weight:392.40Irinotecan EP Impurity E (Irinotecan USP Related Compound B, (S)-7-Ethyl-10-Hydroxy Camptothecin)
CAS:Formula:C22H20N2O5Color and Shape:Pale Yellow SolidMolecular weight:392.417-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:Color and Shape:Light Yellow To YellowSN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Light-Yellow SolidMolecular weight:392.47-Ethyl-10-hydroxycamptothecin
CAS:7-Ethyl-10-hydroxycamptothecin (also known as SN38) is a metabolite of irinotecan hydrochloride (CPT-11). SN38 is a topoisomerase I inhibitor and has potential applications as an anti-tumour agent however its water insolubility presents challenges in terms of bioavailability. Topoisomerase I relaxes the tightly bound DNA double helix and breaks one DNA strand to allow for DNA replication, the topoisomerase-DNA complex is short-lived and once DNA replication is complete topoisomerase reforms the DNA strand. SN38 prolongs the lifetime of the topoisomerase I-DNA complex and inhibits the DNA reforming step, as a result cleavage of the second DNA strand can occur leading to cell death.
Formula:C22H20N2O5Purity:Min. 98 Area-%Color and Shape:Off-White Yellow PowderMolecular weight:392.4 g/mol7-Ethyl-10-hydroxy-camptothecin
CAS:Formula:C22H20N2O5Purity:98%Color and Shape:Yellow powderMolecular weight:392.411
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