CAS 86639-62-5
:9-Nitrocamptothecin
Description:
9-Nitrocamptothecin is a synthetic derivative of camptothecin, a compound originally derived from the bark of the Chinese tree Camptotheca acuminata. This compound is characterized by its potent antitumor activity, primarily due to its ability to inhibit the enzyme topoisomerase I, which is crucial for DNA replication and transcription. The chemical structure of 9-nitrocamptothecin includes a nitro group at the 9-position of the camptothecin core, which enhances its cytotoxic properties. It is typically a yellow crystalline solid that is sparingly soluble in water but more soluble in organic solvents. The compound has been studied for its potential use in cancer therapy, particularly in treating various types of solid tumors. However, its clinical application is limited by factors such as toxicity and the development of resistance in cancer cells. Research continues to explore its derivatives and analogs to improve efficacy and reduce side effects in cancer treatment.
Formula:C20H15N3O6
Synonyms:- 9-Nitrocamptothecin (Rubitecan)
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