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CAS 86639-63-6

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10-Aminocamptothecin

Description:
10-Aminocamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This chemical substance is characterized by its structure, which includes a lactone ring that is crucial for its biological activity. It possesses a primary amine group at the 10-position, which enhances its solubility and potential therapeutic efficacy. 10-Aminocamptothecin exhibits potent antitumor activity by inhibiting the enzyme topoisomerase I, leading to DNA damage and apoptosis in cancer cells. It is primarily studied for its potential use in cancer chemotherapy, particularly against various solid tumors. The compound is typically administered in a controlled manner due to its cytotoxic effects, and ongoing research aims to optimize its pharmacological properties and minimize side effects. Additionally, its stability and solubility characteristics are of interest in formulation development for clinical applications. Overall, 10-Aminocamptothecin represents a significant area of research in the field of oncology and drug development.
Formula:C20H17N3O4
InChI:InChI=1/C20H17N3O4/c1-2-20(26)14-7-16-17-11(5-10-6-12(21)3-4-15(10)22-17)8-23(16)18(24)13(14)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1
InChI key:InChIKey=MVUUMBZAHAKPKQ-FQEVSTJZSA-N
SMILES:O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(N)C4)=CC5=C1COC(=O)[C@@]5(CC)O
Synonyms:
  • (4S)-9-Amino-4-ethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
  • (4S)-9-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-amino-4-ethyl-4-hydroxy-, (4S)-
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-amino-4-ethyl-4-hydroxy-, (S)-
  • 9-Amino-20-camptothecin
  • 10-Aminocamptothecin
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-amino-4-ethyl-4-hydroxy-, (4S)-
  • 1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 9-amino-4-ethyl-4-hydroxy-, (S)-
  • Camptothecin, 10-amino-
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