CAS 86672-58-4

URB 754

Description:

URB 754, with the CAS number 86672-58-4, is a chemical compound known for its role as a selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH). This enzyme is responsible for the breakdown of endocannabinoids, which are naturally occurring compounds in the body that interact with cannabinoid receptors. By inhibiting FAAH, URB 754 increases the levels of endocannabinoids, potentially enhancing their effects on pain, mood, and other physiological processes. The compound is often studied in the context of neuropharmacology and has been investigated for its potential therapeutic applications in conditions such as anxiety, depression, and pain management. URB 754 is characterized by its specific binding affinity to FAAH, which distinguishes it from other compounds that may affect the endocannabinoid system. Its chemical structure includes functional groups that contribute to its biological activity, making it a subject of interest in medicinal chemistry and drug development. However, as with any pharmacological agent, further research is necessary to fully understand its efficacy and safety profile in clinical settings.

Formula: C₁₆H₁₄N₂O₂

InChI: InChI=1/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)

InChI key: InChIKey=GFWNGVKCDGYFKG-UHFFFAOYSA-N

SMILES: O=C1C=2C(N=C(NC3=CC=C(C)C=C3)O1)=CC=C(C)C2

Synonyms:

• 4H-3,1-Benzoxazin-4-one, 6-methyl-2-[(4-methylphenyl)amino]-
• 6-methyl-2-(4-toluidino)-4H-3,1-benzoxazin-4-one
• Urb 754
• Urb754
• 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
• 6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one
• -tolylamino)-4
• 6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one
• 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one
• -3,1-benzoxazin-4-one
• H
• p
• URB754, >=98%
• 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
• 6-Methyl-2-(

6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one

CAS: 86672-58-4

Formula: C₁₆H₁₄N₂O₂

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 266.30

Ref: 3B-M2572

URB754

CAS: 86672-58-4

Formula: C₁₆H₁₄N₂O₂

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 266.2946

Ref: IN-DA008FA5

URB754

CAS: 86672-58-4

"URB754 inhibits rat MAGL with an IC50 of 200 nM, possibly due to impurity. Weak FAAH and CB1 binding, no COX inhibition. Potential pain management target."

Formula: C₁₆H₁₄N₂O₂

Color and Shape: Solid

Molecular weight: 266.29

Ref: TM-T37374

URB754

Controlled Product

CAS: 86672-58-4

Applications URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 µM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 µM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 µM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
References Makara, J.K., et al.: Nat. Neurosci., 8, 1139 (2005)

Formula: C₁₆H₁₄N₂O₂

Color and Shape: Neat

Molecular weight: 266.29

Ref: TR-U822000

URB754

Controlled Product

CAS: 86672-58-4

URB754 is a synthetic cannabinoid that inhibits enzyme activity by binding to the serine protease, lipoprotein lipase, and fatty acid amide hydrolase. It also has been shown to have anti-inflammatory effects in cell cultures. URB754 is synthesized from the natural endocannabinoid anandamide by blocking its reuptake and degradation. It can be used to treat metabolic disorders such as diabetes and obesity.

Formula: C₁₆H₁₄N₂O₂

Purity: Min. 95%

Molecular weight: 266.29 g/mol

Ref: 3D-FU28642