CAS 867-13-0

Triethyl phosphonoacetate

Description:

Triethyl phosphonoacetate, with the CAS number 867-13-0, is an organophosphorus compound characterized by its phosphonate functional group. It appears as a colorless to pale yellow liquid with a fruity odor. This compound is known for its role as a versatile reagent in organic synthesis, particularly in the formation of α-amino acids and other derivatives. It features three ethyl groups attached to a phosphorus atom, contributing to its lipophilicity and solubility in organic solvents. Triethyl phosphonoacetate is also recognized for its ability to act as a phosphonate ester, which can undergo hydrolysis under acidic or basic conditions. Additionally, it is utilized in the synthesis of various pharmaceuticals and agrochemicals, highlighting its importance in both medicinal chemistry and agricultural applications. Safety precautions should be observed when handling this compound, as it may pose health risks if ingested or inhaled. Overall, triethyl phosphonoacetate is a valuable compound in synthetic organic chemistry due to its reactivity and functional versatility.

Formula: C₈H₁₇O₅P

InChI: InChI=1S/C8H17O5P/c1-4-11-8(9)7-14(10,12-5-2)13-6-3/h4-7H2,1-3H3

InChI key: InChIKey=GGUBFICZYGKNTD-UHFFFAOYSA-N

SMILES: P(CC(OCC)=O)(OCC)(OCC)=O

Synonyms:

• (Diethoxyphosphinyl)acetic acid ethyl ester
• (Diethoxyphosphoryl)acetic acid ethyl ester
• (Ethoxycarbonylmethyl)-diethoxyphosphine oxide
• 2-Phosphonoacetic acid triethyl ester
• Acetate, (Diethoxyphosphinyl)-, Ethyl
• Acetic acid, (diethoxyphosphinyl)-, ethyl ester
• Acetic acid, 2-(diethoxyphosphinyl)-, ethyl ester
• Acetic acid, phosphono-, triethyl ester
• Carbethoxymethyldiethyl phosphonate
• Diethyl 2-ethoxy-2-oxoethylphosphonate
• Diethyl carbethoxymethylphosphonate
• Diethyl ethoxycarbonylmethanephosphonate
• Diethyl ethoxycarbonylmethylphosphonate
• Diethyl phosphonoacetic acid ethyl ester
• Ethyl (Diethoxyphosphoryl)Acetate
• Ethyl (diethoxyphosphinyl)acetate
• Ethyl (diethylphosphono)acetate
• Ethyl 2-(diethoxylphosphoryl)acetate
• Ethyl 2-(diethoxyphosphinyl)acetate
• Ethyl 2-(diethoxyphosphoryl)acetate
• Ethyl 2-(diethylphosphono)acetate
• Ethyl α-diethylphosphonoacetate
• Fosfonoacetato De Trietilo
• Jc 224
• Nsc 13898
• Nsc 16128
• Phosphonoacetate de triethyle
• Phosphonoacetic acid triethyl ester
• Triethyl 2-phosphonoacetate
• Triethyl phosphonacetate
• Triethyl phosphonacetic acid
• Triethylphosphonoacetat
• Triethylphosphonoacetate:

Triethyl Phosphonoacetate

CAS: 867-13-0

Formula: C₈H₁₇O₅P

Purity: >97.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 224.19

Ref: 3B-D1523

Triethyl phosphonoacetate, 98+%

CAS: 867-13-0

Triethyl phosphonoacetate serves as a reactant used in Horner-Wadsworth-Emmons reactions, Tsuji-Trost type reactions, Intramolecular Heck-type cyclization and isomerizations and Intramolecular aryne-ene reactions. In Horner-Wadsworth-Emmons reaction, it is utilized as a reagent to prepare chiral 2-

Formula: C₈H₁₇O₅P

Purity: 98+%

Color and Shape: Clear colorless, Liquid

Molecular weight: 224.19

Ref: 02-A14120

Ethyl 2-(diethoxyphosphoryl)acetate

CAS: 867-13-0

Formula: C₈H₁₇O₅P

Purity: 98%

Color and Shape: Liquid

Molecular weight: 224.1913

Ref: IN-DA003PIB

Triethyl phosphonoacetate

CAS: 867-13-0

Formula: C₈H₁₇O₅P

Purity: ≥ 99.0%

Color and Shape: Colourless to light yellow liquid

Molecular weight: 224.19

Ref: 7W-GK5481

Diethyl [(ethoxycarbonyl)methyl]phosphonate

CAS: 867-13-0

Diethyl [(ethoxycarbonyl)methyl]phosphonate

Formula: C₈H₁₇O₅P

Purity: ≥95%

Color and Shape: clear. colourless liquid

Molecular weight: 224.19134g/mol

Ref: 54-OR10710

Phosphonoacetic acid-triethyl ester

CAS: 867-13-0

Formula: C₈H₁₇O₅P

Color and Shape: Neat

Molecular weight: 224.19

Ref: 04-C16144500

Triethyl phosphonoacetate

CAS: 867-13-0

Formula: C₈H₁₇O₅P

Purity: 99.0%

Color and Shape: Clear

Molecular weight: 224.193

Ref: 10-F001326

Minodronic Acid Impurity 12

CAS: 867-13-0

Formula: C₈H₁₇O₅P

Molecular weight: 224.19

Ref: 4Z-M-093017

Triethyl Phosphonoacetate

Controlled Product

CAS: 867-13-0

Applications Reagent used for Horner-Emmons modification.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),

Formula: C₈H₁₇O₅P

Color and Shape: Colourless

Molecular weight: 224.19

Ref: TR-T777000

Ethyl 2-(diethoxyphosphoryl)acetate (Ticagrelor Impuruity)

CAS: 867-13-0

Purity: 98%

Molecular weight: 224.08

Ref: 10-F003599

Triethyl phosphonoacetate

CAS: 867-13-0

Triethyl phosphonoacetate is a dpp-iv inhibitor that has been shown to have beneficial effects on congestive heart failure. It is a pyrimidine compound that can be synthesized in an asymmetric synthesis reaction. The hydroxyl group on the triethyl phosphonoacetate molecule reacts with potassium dichromate to form a reactive intermediate, which undergoes hydrolysis by hydrochloric acid to release acetaldehyde. Acetaldehyde then reacts with malonic acid to produce triethyl phosphonoacetate. Triethyl phosphonoacetate has been shown to have biological properties that are similar to those of other dpp-iv inhibitors, and it has also been shown to have receptor binding activity.

Formula: C₈H₁₇O₅P

Purity: Min. 98%

Color and Shape: Colorless Clear Liquid

Molecular weight: 224.19 g/mol

Ref: 3D-FT28426