CAS 868049-49-4

Olodaterol

Description:

Olodaterol is a long-acting beta-2 adrenergic agonist (LABA) primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It functions by relaxing the muscles in the airways, leading to bronchodilation and improved airflow. The chemical formula of olodaterol is C19H22N2O4S, and it features a thiophene ring, which contributes to its pharmacological properties. Olodaterol is characterized by its prolonged duration of action, allowing for once-daily dosing, which enhances patient compliance. It is typically administered via inhalation, utilizing a specific delivery device designed to ensure optimal lung deposition. The substance has a favorable safety profile, with common side effects including headache, nasopharyngitis, and cough. As a selective agonist, olodaterol exhibits minimal cardiovascular effects compared to non-selective beta agonists, making it a preferred choice in respiratory therapy. Its development represents a significant advancement in the treatment of obstructive airway diseases, providing patients with improved symptom control and quality of life.

Formula: C₂₁H₂₆N₂O₅

InChI: InChI=1S/C21H26N2O5/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26)/t18-/m0/s1

InChI key: InChIKey=COUYJEVMBVSIHV-SFHVURJKSA-N

SMILES: [C@@H](CNC(CC1=CC=C(OC)C=C1)(C)C)(O)C2=C3C(=CC(O)=C2)NC(=O)CO3

Synonyms:

• 6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
• Striverdi Respimat
• 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-
• Olodaterol
• BI 1744

Olodaterol

CAS: 868049-49-4

Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors

Formula: C₂₁H₂₆N₂O₅

Purity: 98.9%

Color and Shape: Solid

Molecular weight: 386.45

Ref: TM-T3457

Olodaterol

CAS: 868049-49-4

Formula: C₂₁H₂₆N₂O₅

Molecular weight: 386.45

Ref: 4Z-O-098001

Olodaterol-d3 Hydrochloride

Controlled Product

CAS: 868049-49-4

Stability Hygroscopic
Applications Olodaterol-d3 is labelled Olodaterol (O262000) which is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).
References Cazzola, M., et al.: Pharmacol. Rev., 64, 450 (2012); Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);

Formula: C₂₁H₂₄D₃ClN₂O₅

Color and Shape: Neat

Molecular weight: 425.92

Ref: TR-O262002

Olodaterol

Controlled Product

CAS: 868049-49-4

β2-sdrenoceptor agonist; bronchodilator

Formula: C₂₁H₂₆N₂O₅

Purity: Min. 95%

Ref: 3D-FH152793

6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one

CAS: 868049-49-4

Formula: C₂₁H₂₆N₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 386.4415

Ref: IN-DA00H1JA