CAS 868540-22-1

(αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide

Description:

The chemical substance with the name "(αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide" and CAS number "868540-22-1" is a complex organic compound characterized by its intricate structure, which includes multiple functional groups such as amides, carbonyls, and an epoxide. This compound is likely to exhibit specific stereochemistry, as indicated by the presence of chiral centers, which can influence its biological activity and interactions. The presence of the dimethylethoxycarbonyl group suggests potential applications in medicinal chemistry, particularly in drug design, where such modifications can enhance solubility and bioavailability. Additionally, the compound's structure may confer specific pharmacological properties, making it a candidate for further investigation in therapeutic contexts. Its synthesis and characterization would require advanced techniques in organic chemistry, including chromatography and spectroscopy, to confirm purity and structural integrity. Overall, this compound exemplifies the complexity often found in bioactive molecules used in pharmaceutical research.

Formula: C₃₉H₅₆N₄O₇

InChI: InChI=1S/C39H56N4O7/c1-25(2)21-30(33(44)39(8)24-49-39)40-36(47)32(23-28-17-13-10-14-18-28)42-35(46)31(22-26(3)4)41-34(45)29(43-37(48)50-38(5,6)7)20-19-27-15-11-9-12-16-27/h9-18,25-26,29-32H,19-24H2,1-8H3,(H,40,47)(H,41,45)(H,42,46)(H,43,48)/t29-,30-,31-,32-,39+/m0/s1

InChI key: InChIKey=ZHBDLOMPGLZDJI-ZSMRNREKSA-N

SMILES: C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CC(C)C)=O)=O)CC(C)C)(=O)[C@@]3(C)CO3

Synonyms:

• (αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide
• L-Phenylalaninamide, (αS)-α-[[(1,1-dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-
• L-Phenylalaninamide, (αS)-α-[[(1,1-dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
• (2R)-2-[(2S)-2-[[N-[(S)-2-(tert-Butoxycarbonylamino)-4-phenylbutanoyl]-L-leucyl-L-phenylalanyl]amino]-4-methylpentanoyl]-2-methyloxirane

Carfilzomib Impurity 9

CAS: 868540-22-1

Formula: C₃₉H₅₆N₄O₇

Molecular weight: 692.90

Ref: 4Z-C-121012

N-Des-4-morpholineacetic Acid N-Boc-Carfilzomib

Controlled Product

CAS: 868540-22-1

Applications N-Des-4-morpholineacetic Acid N-Boc-Carfilzomib is an impurity of Carfilzomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Formula: C₃₉H₅₆N₄O₇

Color and Shape: Neat

Molecular weight: 692.885

Ref: TR-D292970

Carfilzomib Impurity 9 (RSSSS)

CAS: 868540-22-1

Formula: C₃₉H₅₆N₄O₇

Molecular weight: 692.9

Ref: ST-EA-CP-C153008