CAS 868771-57-7

Melogliptin

Description:

Melogliptin is a chemical compound classified as a DPP-4 (dipeptidyl peptidase-4) inhibitor, primarily used in the management of type 2 diabetes mellitus. It works by enhancing the levels of incretin hormones, which help to regulate glucose metabolism by increasing insulin secretion and decreasing glucagon levels in response to meals. Melogliptin is characterized by its ability to improve glycemic control with a relatively low risk of hypoglycemia. The compound is typically administered orally and has a favorable pharmacokinetic profile, including a moderate half-life that allows for once-daily dosing. Its chemical structure includes specific functional groups that contribute to its biological activity and selectivity for the DPP-4 enzyme. As with other medications, potential side effects may include gastrointestinal disturbances, and it is essential for patients to consult healthcare professionals for personalized medical advice. Overall, Melogliptin represents a valuable option in the therapeutic arsenal for managing diabetes, particularly for patients who require additional glycemic control.

Formula: C₁₅H₂₁FN₆O

Synonyms:

• (2S,4S)-4-Fluoro-1-[2-[[(1R,3S)-3-(1H-1,2,4-triazol-1-ylmethyl)cyclopentyl]amino]acetyl]-2-pyrrolidinecarbonitrile

Melogliptin

CAS: 868771-57-7

Melogliptin is a synthetic drug that inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which regulates the production of insulin. It has a potent inhibitory effect on DPP-IV, which is an enzyme that breaks down the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Melogliptin has been shown to reduce blood sugar levels in patients with type 2 diabetes mellitus. The drug is also an analog of pioglitazone, a thiazolidinedione antidiabetic agent. Melogliptin binds to fatty acid receptors in cells and inhibits the activity of serine proteases, such as DPP-IV, which are involved in regulating insulin resistance.

Formula: C₁₅H₂₁FN₆O

Purity: Min. 95%

Molecular weight: 320.37 g/mol

Ref: 3D-FM103531

Melogliptin

CAS: 868771-57-7

Melogliptin (EMD-675992, GRC-8200) is a DPP-IV inhibitor for type II diabetes, lowering HbA1c up to 0.75%.

Formula: C₁₅H₂₁FN₆O

Color and Shape: Solid

Molecular weight: 320.37

Ref: TM-T68491