3',5'-Di-O-acetyl-5-fluoro-2'-O-methyl-O4-(2,4,6-trimethylphenyl)uridine is a modified nucleoside with several notable characteristics. This compound features a uridine backbone, which is a nucleoside composed of a ribose sugar and a uracil base. The presence of acetyl groups at the 3' and 5' positions enhances its stability and solubility, while the 5-fluoro substitution introduces a fluorine atom that can influence its biological activity and interaction with nucleic acids. The 2'-O-methyl modification further increases its resistance to enzymatic degradation, making it a valuable candidate for therapeutic applications, particularly in the field of RNA-based drugs. The bulky 2,4,6-trimethylphenyl group at the O4 position may affect the compound's binding affinity and specificity towards RNA targets. Overall, this compound exemplifies the strategic modifications made to nucleosides to improve their pharmacological properties, making them useful in research and potential therapeutic contexts.

3',5'-DI-O-ACETYL-5-FLUORO-2'-O-METHYL-O4-(2,4,6-TRIMETHYLPHENYL)URIDINE

869355-32-8: 3',5'-Di-O-acetyl-5-fluoro-2'-O-methyl-O4-(2,4,6-trimethylphenyl)uridine is a modified nucleoside with several notable characteristics. This compound features a uridine backbone, which is a nucleoside composed of a ribose sugar and a uracil base. The presence of acetyl groups at the 3' and 5' positions enhances its stability and solubility, while the 5-fluoro substitution introduces a fluorine atom that can influence its biological activity and interaction with nucleic acids. The 2'-O-methyl modification further increases its resistance to enzymatic degradation, making it a valuable candidate for therapeutic applications, particularly in the field of RNA-based drugs. The bulky 2,4,6-trimethylphenyl group at the O4 position may affect the compound's binding affinity and specificity towards RNA targets. Overall, this compound exemplifies the strategic modifications made to nucleosides to improve their pharmacological properties, making them useful in research and potential therapeutic contexts.

<p>3',5'-Di-O-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-O-methyluridine is a novel monophosphate nucleoside analog that is activated by T4 polynucleotide kinase. It is synthesized from the corresponding phosphoramidite and reacts with the 5'-OH group of a ribonucleoside to form a 3',5'-di-O-acetylribonucleoside. The diacetyl group confers increased stability to the molecule and also provides an acetyl group for incorporation into DNA. This compound has antiviral activity against herpes simplex virus type 1 (HSV1) in cell culture and has shown anticancer properties in animal studies.</p>

CAS 869355-32-8

3',5'-DI-O-ACETYL-5-FLUORO-2'-O-METHYL-O4-(2,4,6-TRIMETHYLPHENYL)URIDINE

3',5'-Di-o-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-o-methyluridine

Ref: 3D-UJB35532