CAS 869477-96-3

Olodaterol hydrochloride

Description:

Olodaterol hydrochloride is a long-acting beta-2 adrenergic agonist (LABA) primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It functions by relaxing the muscles in the airways, leading to improved airflow and easier breathing. The substance is characterized by its high selectivity for beta-2 adrenergic receptors, which minimizes cardiovascular side effects commonly associated with non-selective beta agonists. Olodaterol hydrochloride is typically administered via inhalation, allowing for targeted delivery to the lungs. Its pharmacokinetic profile includes a prolonged duration of action, enabling once-daily dosing, which enhances patient compliance. The compound is generally well-tolerated, with common side effects including headache, nasopharyngitis, and cough. As with other LABAs, it is recommended to be used in conjunction with inhaled corticosteroids for optimal asthma management. The chemical structure of olodaterol includes a chiral center, contributing to its specific pharmacological activity. Overall, olodaterol hydrochloride represents a significant advancement in the treatment of respiratory conditions, providing effective bronchodilation with a favorable safety profile.

Formula: C₂₁H₂₆N₂O₅·ClH

InChI: InChI=1S/C21H26N2O5.ClH/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17;/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26);1H/t18-;/m0./s1

InChI key: InChIKey=KCEHVJZZIGJAAW-FERBBOLQSA-N

SMILES: [C@@H](CNC(CC1=CC=C(OC)C=C1)(C)C)(O)C2=C3C(=CC(O)=C2)NC(=O)CO3.Cl

Synonyms:

• 2H-3,1-Benzoxazin-2-one 1,4-dihydro-7-hydroxy-5-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-
• BI 1744 hydrochloride
• 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-, monohydrochloride
• 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-, hydrochloride (1:1)
• Olodaterol hydrochloride

OLODATEROL FOR IMPURITY A IDENTIFICATION CRS

CAS: 869477-96-3

OLODATEROL FOR IMPURITY A IDENTIFICATION CRS

Ref: 41-Y0002500

OLODATEROL HYDROCHLORIDE CRS

CAS: 869477-96-3

OLODATEROL HYDROCHLORIDE CRS

Ref: 41-Y0002495

6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

CAS: 869477-96-3

Formula: C₂₁H₂₇ClN₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 422.9025

Ref: IN-DA01CBVI

Olodaterol hydrochloride

CAS: 869477-96-3

Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist that exerts its pharmacological effect by binding and activating β2-AR.

Formula: C₂₁H₂₇ClN₂O₅

Purity: 99.11%

Color and Shape: Solid

Molecular weight: 422.9

Ref: TM-T5159

Olodaterol Hydrochloride

Controlled Product

CAS: 869477-96-3

Applications Olodaterol is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).
References Cazzola, M., et al.: Pharmacol. Rev., 64, 450 (2012); Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);

Formula: C₂₁H₂₇ClN₂O₅

Color and Shape: Off-White To Light Brown

Molecular weight: 422.90

Ref: TR-O262000

Olodaterol Glucuronide

Controlled Product

CAS: 869477-96-3

Formula: C₂₇H₃₄N₂O₁₁

Color and Shape: Neat

Molecular weight: 562.566

Ref: TR-O262015

Olodaterol hydrochloride

Controlled Product

CAS: 869477-96-3

Olodaterol hydrochloride is a long-acting β2-agonist (LABA) used to treat asthma. It is a prodrug that is hydrolyzed in vivo to olodaterol, its active form. Olodaterol hydrochloride binds to the β2 receptor and activates adenylyl cyclase, resulting in increased levels of cAMP. This drug has been shown to have statistically significant improvement in lung function and bronchial responsiveness in vivo models. The most common adverse effects include headache, dizziness, and cough. Olodaterol hydrochloride has been shown to be effective for short-term treatment of asthma but does not show long-term efficacy or reduced need for pharmacological treatments.

Formula: C₂₁H₂₆N₂O₅·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 422.9 g/mol

Ref: 3D-FO156964