CAS 869791-42-4

PeMetrexed EP IMpurity A

Description:

PeMetrexed EP Impurity A, identified by the CAS number 869791-42-4, is a chemical compound that is typically associated with the pharmaceutical industry, particularly in the context of cancer treatment. It is an impurity related to pemetrexed, a multi-targeted antifolate used in chemotherapy for certain types of cancer, including mesothelioma and non-small cell lung cancer. The characteristics of this impurity may include its molecular structure, which is likely to be similar to that of pemetrexed but with slight variations that affect its pharmacological properties. Impurities like PeMetrexed EP Impurity A are often characterized by their solubility, stability, and potential biological activity, which can influence the overall efficacy and safety profile of the drug formulation. Regulatory guidelines typically require the identification and quantification of such impurities to ensure the quality and safety of pharmaceutical products. Understanding the characteristics of impurities is crucial for drug development and quality control processes in the pharmaceutical industry.

Formula: C₂₁H₂₃N₅O₆

Synonyms:

• PeMetrexed EP IMpurity A
• (sodium (S)-2-(4-(2-(2-amino-1-methyl
• Pemetrexed EP Imp A
• Pemetrexed Impurity 2(Pemetrexed EP Impurity A)
• Pemetrexed disodium EP impurity A
• Pemetrexed BP Impurity A
• PeMetrexed IMpurity
• Pemetrexed impurity 1/Pemetrexed EP Impurity A/(4-(2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• Pemetrexed EP Impurity A (N-methyl Pemetrexed)
• JKULRGFPYBAJTE-AWEZNQCLSA-N

N-Methyl Pemetrexed ({4-[2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid)

CAS: 869791-42-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₂₁H₂₃N₅O₆

Color and Shape: Light Yellow Solid

Molecular weight: 441.16483

Ref: 45-1A08270

N-Methyl pemetrexed

CAS: 869791-42-4

N-Methyl pemetrexed, an impurity found in Pemetrexed, serves as an antifolate cytotoxic agent utilized in cancer research [1].

Formula: C₂₁H₂₃N₅O₆

Color and Shape: Solid

Molecular weight: 441.44

Ref: TM-T74111

(S)-2-(4-(2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

CAS: 869791-42-4

(S)-2-(4-(2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Purity: 98%

Molecular weight: 441.44g/mol

Ref: 54-OR1067145

Pemetrexed EP Impurity A

CAS: 869791-42-4

Formula: C₂₁H₂₃N₅O₆

Molecular weight: 441.44

Ref: 4Z-P-689

(2S)-2-[[4-[2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic Acid

CAS: 869791-42-4

Color and Shape: Neat

Ref: 86-MM1301.01

N-Methyl Pemetrexed

Controlled Product

CAS: 869791-42-4

Impurity Pemetrexed EP Impurity A
Applications N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.
References Kjell, D.P., et al.: Org. Proc. Res. Develop., 9, 738 (2005);

Formula: C₂₁H₂₃N₅O₆

Color and Shape: Neat

Molecular weight: 441.44

Ref: TR-M325465

Pemetrexed EP Impurity A

CAS: 869791-42-4

Pemetrexed EP Impurity A is a by-product of the synthesis of pemetrexed, which is a drug used to treat cancer. It has been shown to have cytotoxic activity against lung cancer cells in vitro and in vivo. Pemetrexed EP Impurity A inhibits glutamic acid decarboxylase, which is an enzyme that converts glutamate into gamma-aminobutyric acid (GABA). This inhibition leads to the accumulation of glutamate, leading to cell death. The compound has also been shown to inhibit malignant pleural mesothelioma cells in vitro and in vivo.

Formula: C₂₁H₂₃N₅O₆

Purity: Min. 95%

Molecular weight: 441.4 g/mol

Ref: 3D-IP179744