Platencin is a synthetic compound that belongs to the class of antibiotics, specifically a member of the platensimycin family. It is notable for its broad-spectrum antibacterial activity, particularly against Gram-positive bacteria, including strains resistant to conventional antibiotics. The compound functions by inhibiting fatty acid biosynthesis, which is essential for bacterial cell membrane formation. Platencin exhibits a unique mechanism of action, targeting two distinct enzymes involved in this biosynthetic pathway, making it a promising candidate for addressing antibiotic resistance. Its chemical structure features a complex bicyclic core, contributing to its biological activity. Research has indicated that platencin has potential applications in treating infections caused by multidrug-resistant pathogens. However, further studies are necessary to fully understand its pharmacokinetics, toxicity, and therapeutic potential in clinical settings. As of the latest data, platencin remains primarily of interest in research contexts, with ongoing investigations into its efficacy and safety profiles.

Platencin is a natural, broad spectrum Gram-
positive antibiotic isolated from
S. platensis
, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-
ketoacyl-
ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC
50
values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-
resistance to antibiotic resistant bacterial strains, including methicillin-
resistant
S. aureus
, vancomycin-
intermediate
S. aureus
, and vancomycin-
resistant
Enterococci
. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.

Platencin

869898-86-2: Platencin is a synthetic compound that belongs to the class of antibiotics, specifically a member of the platensimycin family. It is notable for its broad-spectrum antibacterial activity, particularly against Gram-positive bacteria, including strains resistant to conventional antibiotics. The compound functions by inhibiting fatty acid biosynthesis, which is essential for bacterial cell membrane formation. Platencin exhibits a unique mechanism of action, targeting two distinct enzymes involved in this biosynthetic pathway, making it a promising candidate for addressing antibiotic resistance. Its chemical structure features a complex bicyclic core, contributing to its biological activity. Research has indicated that platencin has potential applications in treating infections caused by multidrug-resistant pathogens. However, further studies are necessary to fully understand its pharmacokinetics, toxicity, and therapeutic potential in clinical settings. As of the latest data, platencin remains primarily of interest in research contexts, with ongoing investigations into its efficacy and safety profiles.

<p>Platencin, a broad-spectrum antibiotic from S. platensis, inhibits FabF and FabH, with IC50s of 1.95 and 3.91 μg/ml; fights resistant bacteria.</p>

CAS 869898-86-2

Platencin

Platencin

Ref: 7W-GA2151

Platencin

Ref: TM-T38125