CAS 870653-45-5

5-(4-Phenoxybutoxy)psoralen

Description:

5-(4-Phenoxybutoxy)psoralen is a synthetic organic compound that belongs to the class of psoralens, which are known for their ability to intercalate with DNA and are often used in phototherapy for skin conditions such as psoriasis and vitiligo. This compound features a psoralen core structure, which is characterized by a fused coumarin and furan ring system, and is substituted with a 4-phenoxybutoxy group that enhances its solubility and biological activity. The presence of the phenoxybutoxy moiety contributes to its lipophilicity, potentially improving its ability to penetrate biological membranes. 5-(4-Phenoxybutoxy)psoralen can exhibit phototoxic effects when exposed to ultraviolet light, leading to DNA cross-linking and subsequent cellular responses. Its pharmacological properties may include immunomodulatory effects, making it a subject of interest in dermatological research. As with many psoralens, safety considerations regarding its use, particularly in light of potential side effects and interactions, are essential for therapeutic applications.

Formula: C₂₁H₁₈O₅

InChI: InChI=1/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2

SMILES: c1ccc(cc1)OCCCCOc1c2ccc(=O)oc2cc2c1cco2

Synonyms:

• 4-(4-Phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
• 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one

5-(4-Phenoxybutoxy)psoralen

CAS: 870653-45-5

Formula: C₂₁H₁₈O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 350.3646

Ref: IN-DA004JDG

5-(4-Phenoxybutoxy)psoralen

CAS: 870653-45-5

Formula: C₂₁H₁₈O₅

Purity: ≥ 98.0%

Color and Shape: White to light-yellow solid or powder

Molecular weight: 350.36

Ref: 7W-GL4434

PAP-1

CAS: 870653-45-5

PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).

Formula: C₂₁H₁₈O₅

Purity: 99.35% - 99.75%

Color and Shape: White Solid

Molecular weight: 350.36

Ref: TM-TQ0179

5-(4-Phenoxybutoxy)psoralen

Controlled Product

CAS: 870653-45-5

Formula: C₂₁H₁₈O₅

Color and Shape: Neat

Molecular weight: 350.365

Ref: TR-P069500

4-(4-Phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one

Controlled Product

CAS: 870653-45-5

4-(4-Phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one is a chromene derivative. It has been shown to suppress the production of inflammatory cytokines such as tumor necrosis factor and interleukin 4 in vitro. 4-(4-Phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one also inhibits the activity of protein phosphatase 1 (PP1) and PP2B, which are enzymes that regulate the activity of other proteins by dephosphorylating them. The compound also suppresses the production of cytokines in wild type mice by inhibiting macrophages from releasing proinflammatory cytokines. Microglia cells are also suppressed from producing inflammatory mediators. These properties make 4-(4-Phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one an attractive

Purity: Min. 95%

Ref: 3D-FP142327