CYM-5478, identified by its CAS number 870762-83-7, is a chemical compound that has garnered attention in pharmaceutical research, particularly for its potential therapeutic applications. As a small molecule, it is characterized by its specific structural features that contribute to its biological activity. The compound is typically evaluated for its efficacy, safety, and mechanism of action in various biological systems. While detailed information on its pharmacokinetics and pharmacodynamics may vary, compounds like CYM-5478 are often studied for their interactions with specific biological targets, which can include enzymes or receptors involved in disease processes. Additionally, the compound's solubility, stability, and reactivity are crucial for its development as a drug candidate. Research into CYM-5478 may also explore its potential side effects and optimal dosing regimens. Overall, the characteristics of CYM-5478 reflect its role in ongoing investigations aimed at discovering new therapeutic agents.

CYM 5478 is a sphingosine-1-phosphate receptor 2 (S1P
2
) agonist (EC
50
= 0.78 μM in a reporter assay). It is selective for S1P
2
over S1P
1
and S1P
3-5
in a TGFα-shedding assay (EC
50
s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin in C6 cells when used at a concentration of 10 μM.

CYM-5478

870762-83-7: CYM-5478, identified by its CAS number 870762-83-7, is a chemical compound that has garnered attention in pharmaceutical research, particularly for its potential therapeutic applications. As a small molecule, it is characterized by its specific structural features that contribute to its biological activity. The compound is typically evaluated for its efficacy, safety, and mechanism of action in various biological systems. While detailed information on its pharmacokinetics and pharmacodynamics may vary, compounds like CYM-5478 are often studied for their interactions with specific biological targets, which can include enzymes or receptors involved in disease processes. Additionally, the compound's solubility, stability, and reactivity are crucial for its development as a drug candidate. Research into CYM-5478 may also explore its potential side effects and optimal dosing regimens. Overall, the characteristics of CYM-5478 reflect its role in ongoing investigations aimed at discovering new therapeutic agents.

<p>CYM-5478, a strong S1P2 agonist, boosts C6 cell survival over 100nM under serum-starvation.</p>

CAS 870762-83-7

CYM-5478

CYM-5478

Ref: TM-T27107