CAS 87081-36-5

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Description:

The chemical substance with the name "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid" and CAS number "87081-36-5" is a complex organic compound characterized by its multiple stereocenters and functional groups. It features a long carbon chain with several double bonds, indicating it is likely a polyunsaturated fatty acid derivative. The presence of hydroxyl and keto groups suggests it may exhibit significant reactivity and potential biological activity. The specific stereochemistry, denoted by the (E) and (Z) configurations, implies that the compound may have unique spatial arrangements affecting its interactions in biological systems. Such compounds are often studied for their roles in natural products, potential therapeutic applications, or as intermediates in synthetic chemistry. Overall, this substance exemplifies the complexity and diversity found in organic chemistry, particularly in the realm of natural product synthesis and modification.

Formula: C₃₂H₄₆O₆

InChI: InChI=1/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+

InChI key: InChIKey=QECBVZBMGUAZDL-WRDLAOIUSA-N

SMILES: C(=C/C(=C\[C@@H](C/C=C/C(=C/[C@H](C([C@H]([C@@H]([C@H](C/C(=C/C(O)=O)/C)C)O)C)=O)C)/C)C)/C)\[C@H]1[C@@H](C)C=CC(=O)O1

Synonyms:

• (2E,10E,12E,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-, (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
• Jildamycin
• Leptomycin A
• NSC 369326
• QECBVZBMGUAZDL-DLWOFZAMSA-N
• 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
• Antibiotic ATS-1287A
• PD-118607
• ATS 1287A, PD 118607, JildaMycin
• 19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• Antibiotic PD-118607

Leptomycin A

CAS: 87081-36-5

Formula: C₃₂H₄₆O₆

Molecular weight: 526.7

Ref: 7W-GA3048

Leptomycin A

CAS: 87081-36-5

Leptomycin A

Molecular weight: 526.70g/mol

Ref: 54-BIL2100

Leptomycin A

CAS: 87081-36-5

Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.

Formula: C₃₂H₄₆O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 526.7

Ref: TM-T11837

Leptomycin A

CAS: 87081-36-5

Leptomycin A is a Streptomyces-produced inhibitor, which is derived from the bacterium Streptomyces spiroverticillatus. It functions by specifically binding to and inhibiting the CRM1 (exportin 1), a nuclear export receptor. This action blocks the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES), thereby leading to their accumulation within the nucleus. The inhibition of CRM1 disrupts various cellular processes, including cell cycle regulation and signal transduction pathways.

Formula: C₃₂H₄₆O₆

Purity: Min. 95%

Molecular weight: 526.7 g/mol

Ref: 3D-MDA08136