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CAS 87092-83-9

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chimeramycin B

Description:
Chimeramycin B is a natural product belonging to the class of antibiotics known as anthracyclines, which are characterized by their complex polycyclic structures and ability to intercalate DNA. It is produced by certain strains of the bacterium *Streptomyces chrysomallus*. Chimeramycin B exhibits potent antibacterial and antitumor activities, making it of interest in medicinal chemistry and pharmacology. The compound's mechanism of action primarily involves the inhibition of DNA synthesis, which is crucial for cell division and proliferation. Its structure features multiple functional groups that contribute to its biological activity and solubility properties. Additionally, chimeramycin B has been studied for its potential use in cancer therapy due to its ability to target rapidly dividing cells. Research into its pharmacokinetics, toxicity, and therapeutic efficacy continues to be an area of interest, as scientists explore its potential applications in treating various bacterial infections and cancers.
Formula:C46H80N2O13
InChI:InChI=1/C45H78N2O13/c1-14-34-25(3)19-24(2)15-17-35(58-37-18-16-32(46(10)11)28(6)54-37)26(4)20-31(23-48)41(27(5)33(49)21-36(50)57-34)60-44-40(51)39(47(12)13)42(29(7)56-44)59-38-22-45(9,53)43(52)30(8)55-38/h15,17,19,23,25-35,37-44,49,51-53H,14,16,18,20-22H2,1-13H3/b17-15+,24-19+/t25-,26+,27-,28+,29+,30-,31+,32-,33+,34+,35?,37-,38-,39+,40+,41+,42+,43-,44-,45+/m0/s1
Synonyms:
  • (9R)-23-De[(6-deoxy-2-O,3-O-dimethyl-β-D-allopyranosyl)oxy]-9-deoxo-9-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]tyrosine [antibiotic]
  • chimeramycin B
  • Tylosin, 23-de[(6-deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]-9-deoxo-9-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-, (9R)- (9CI)
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