CAS 87102-70-3

(R)-Propranolol β-D-Glucuronide Sodium Salt

Description:

(R)-Propranolol β-D-Glucuronide Sodium Salt is a chemical compound that serves as a metabolite of the well-known beta-blocker propranolol, which is primarily used to manage hypertension, anxiety, and other cardiovascular conditions. This compound is characterized by its glucuronide conjugation, which enhances the solubility and excretion of propranolol in the body. As a sodium salt, it is typically more soluble in aqueous solutions, facilitating its use in pharmaceutical formulations. The compound exhibits properties typical of glucuronides, including increased polarity and reduced biological activity compared to its parent drug. Its structure includes a β-D-glucuronic acid moiety linked to the propranolol molecule, which contributes to its pharmacokinetic profile. The presence of the sodium ion also plays a role in its stability and solubility. Overall, (R)-Propranolol β-D-Glucuronide Sodium Salt is significant in understanding the metabolism and elimination of propranolol in clinical settings.

Formula: C₂₂H₃₀NNaO₈

Synonyms:

• (R)-Propranolol Glucuronide SodiuM
• (R)-Propranolol β-D-Glucuronide Sodium Salt
• (R)-Propranolol b-D-glucuronide sodium salt
• (+)-Propranolol Glucuronide SodiuM
• sodium,(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-yl]oxyoxane-2-carboxylate
• (R)-1-[[(1-Methylethyl)aMino]Methyl]-2-(1-naphthalenyloxy)ethyl β-D-Glucopyranosiduronic Acid MonosodiuM Salt

(R)-Propranolol b-D-glucuronide sodium salt

CAS: 87102-70-3

Ref: 7W-GC4134

rac Propranolol β-D-Glucuronide Sodium Salt

Controlled Product

CAS: 87102-70-3

Applications A metabolite of Propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).
References Reeves, P., et al.: Xenobiotica, 8, 313 (1978), Balon, K., et al.: Pharm. Res., 16, 882(1999), Lange, R., et al.: Toxicol. Lett., 131, 97 (2002),

Formula: C₂₂H₂₈NNaO₈

Color and Shape: Neat

Molecular weight: 457.45

Ref: TR-P831810

rac Propranolol-d7 β-D-Glucuronide Sodium Salt

Controlled Product

CAS: 87102-70-3, 87144-73-8

Applications A labelled metabolite of Propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).
References Reeves, P., et al.: Xenobiotica, 8, 313 (1978), Balon, K., et al.: Pharm. Res., 16, 882 (1999), Lange, R., et al.: Toxicol. Lett., 131, 97 (2002),

Formula: C₂₂D₇H₂₁NNaO₈

Color and Shape: Neat

Molecular weight: 464.493

Ref: TR-P831812

(R)-Propranolol β-D-Glucuronide Sodium Salt

Controlled Product

CAS: 87102-70-3

Formula: C₂₂H₂₈NO₈·Na

Color and Shape: Neat

Molecular weight: 457.449

Ref: TR-P831815

(R)-Propranolol b-D-glucuronide sodium salt

CAS: 87102-70-3

(R)-Propranolol b-D-glucuronide sodium salt is a synthetic glycosylate prodrug of the β-adrenergic blocker propranolol. It is used for the treatment of hypertension, angina pectoris, and arrhythmias. The compound has been shown to be effective in reducing mortality rates in patients with heart failure or chronic obstructive pulmonary disease (COPD). It is also used as an adjunct therapy for asthma, bronchitis, and emphysema.

Formula: C₂₂H₂₈NNaO₈

Purity: Min. 95%

Molecular weight: 457.45 g/mol

Ref: 3D-MP16840