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CAS 871258-12-7

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DLinDMA

Description:
DLinDMA, or 1,2-dilinoleoyl-3-dimethylammonium propane (CAS 871258-12-7), is a synthetic cationic lipid commonly used in the field of gene delivery and nanomedicine. This compound is characterized by its amphiphilic nature, possessing both hydrophilic and hydrophobic regions, which facilitates the formation of lipid-based nanoparticles or liposomes. DLinDMA is particularly noted for its ability to encapsulate nucleic acids, such as DNA and RNA, enhancing their stability and facilitating cellular uptake. The presence of multiple double bonds in its linoleoyl chains contributes to its fluidity and flexibility, which are advantageous for membrane fusion and endosomal escape during transfection processes. Additionally, the dimethylammonium group imparts a positive charge, promoting interaction with negatively charged cellular membranes. Overall, DLinDMA is a valuable component in the development of lipid formulations for therapeutic applications, particularly in the delivery of genetic material for gene therapy and vaccination strategies.
Formula:C41H77NO2
Synonyms:
  • 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-
  • DLinDMA
  • 1,2-Dilinoleyloxy-N,N-dimethyl-3-aminopropane
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