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CAS 87151-85-7

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Spiradoline

Description:
Spiradoline, with the CAS number 87151-85-7, is a synthetic compound that belongs to the class of kappa-opioid receptor agonists. It is primarily known for its potential analgesic properties and has been studied for its effects on pain modulation. Spiradoline exhibits a unique pharmacological profile, differentiating it from other opioid compounds by its selective action on kappa receptors, which may lead to reduced side effects commonly associated with mu-opioid receptor agonists, such as respiratory depression and addiction potential. The compound has been investigated in various preclinical studies for its efficacy in treating pain and its potential therapeutic applications in conditions like depression and anxiety. Spiradoline's chemical structure includes a bicyclic framework, contributing to its biological activity. However, it is important to note that while it shows promise in research settings, its clinical use is limited, and further studies are necessary to fully understand its safety and efficacy in humans.
Formula:C22H30Cl2N2O2
InChI:InChI=1/C22H30Cl2N2O2/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3/t19-,20-,22-/m0/s1
InChI key:InChIKey=NYKCGQQJNVPOLU-ZODHJFBFNA-N
SMILES:N(C(CC1=CC(Cl)=C(Cl)C=C1)=O)(C)[C@@H]2[C@H](C[C@@]3(CC2)CCCO3)N4CCCC4
Synonyms:
  • 1-Oxaspiro[4.5]decane, benzeneacetamide deriv.
  • 2-(3,4-dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
  • 2-(3,4-dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide methanesulfonate (1:1)
  • Benzeneacetamide, 3,4-dichloro-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)-, (5alpha,7alpha,8beta)-(+-)-
  • Benzeneacetamide, 3,4-dichloro-N-methyl-N-[(5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, rel-
  • Benzeneacetamide, 3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, rel-
  • Benzeneacetamide, 3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, (5α,7α,8β)-
  • Espiradolina
  • Espiradolina [Spanish]
  • Spiradoline [INN]
  • See more synonyms
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