CAS 87171-83-3

3-(2-deoxy-alpha-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one

Description:

3-(2-Deoxy-alpha-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one, with the CAS number 87171-83-3, is a nucleoside analog that exhibits structural features characteristic of both purines and pyrimidines. This compound is notable for its fused pyrimidine and purine rings, which contribute to its potential biological activity. The presence of the 2-deoxy-pentofuranosyl moiety suggests that it may interact with nucleic acids, potentially influencing processes such as DNA or RNA synthesis. Its unique structure allows it to mimic natural nucleosides, making it of interest in medicinal chemistry, particularly in the development of antiviral or anticancer agents. The compound's solubility, stability, and reactivity can vary based on environmental conditions, such as pH and temperature. Additionally, its pharmacological properties, including bioavailability and mechanism of action, would be critical for evaluating its therapeutic potential. Overall, this compound represents a fascinating area of study within the field of nucleoside chemistry and drug development.

Formula: C₁₃H₁₃N₅O₄

InChI: InChI=1/C13H13N5O4/c19-5-8-7(20)4-9(22-8)18-6-15-10-11(18)16-13-14-2-1-3-17(13)12(10)21/h1-3,6-9,19-20H,4-5H2/t7-,8+,9-/m0/s1

Synonyms:

• 3-(2'-deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one
• Pyrimido[1,2-a]purin-10(3H)-one, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-
• 3-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one
• M1G-DR

3-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one

Controlled Product

CAS: 87171-83-3

Applications The major DNA adduct of endogenous carcinogen malondialdehyde.
References Marnett, L., et al.: Mutat. Res., 148, 25 (1985), Rouzer, C., et al.: Chem. Res. Toxicol., 10, 181 (1997), Marnett, L., et al.: Mutat. Res., 424, 83 (1999), Marnett, L., et al.: J. Clin. Invest., 111, 583 (2003),

Formula: C₁₃H₁₃N₅O₄

Color and Shape: Light Yellow Solid

Molecular weight: 303.27

Ref: TR-D232905

3-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one-13C3

Controlled Product

CAS: 87171-83-3

Applications The major labelled DNA adduct of endogenous carcinogen malondialdehyde.
References Marnett, L., et al.: Mutat. Res., 148, 25 (1985), Rouzer, C., et al.: Chem. Res. Toxicol., 10, 181 (1997), Marnett, L., et al.: Mutat. Res., 424, 83 (1999), Marnett, L., et al.: J. Clin. Invest., 111, 583 (2003),

Formula: C₁₀C₃H₁₃N₅O₄

Color and Shape: Neat

Molecular weight: 306.25

Ref: TR-D232907

3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one

CAS: 87171-83-3

3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one is a malondialdehyde-deoxyguanosine adduct.

Formula: C₁₃H₁₃N₅O₄

Color and Shape: Solid

Molecular weight: 303.27

Ref: TM-T29377