CAS 87173-97-5

Spiradoline mesylate

Description:

Spiradoline mesylate is a synthetic compound primarily known for its role as a selective kappa-opioid receptor agonist. It is characterized by its ability to modulate pain perception and has been studied for potential therapeutic applications in pain management and addiction treatment. The mesylate salt form enhances its solubility and stability, making it more suitable for pharmaceutical formulations. Spiradoline exhibits a unique pharmacological profile, distinct from other opioid receptors, which may contribute to its reduced side effects, such as respiratory depression, commonly associated with mu-opioid agonists. The compound's chemical structure includes a bicyclic core, which is essential for its receptor binding affinity. Spiradoline has been investigated in various preclinical and clinical studies, focusing on its efficacy and safety. However, its use is limited due to regulatory considerations and the need for further research to fully understand its therapeutic potential and long-term effects. Overall, Spiradoline mesylate represents an interesting area of study within the field of medicinal chemistry and pain management.

Formula: C₂₂H₃₀Cl₂N₂O₂·CH₄O₃S

InChI: InChI=1/C22H30Cl2N2O2.CH4O3S/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26;1-5(2,3)4/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3;1H3,(H,2,3,4)/t19-,20-,22-;/s2

InChI key: InChIKey=FHEZDPDAYTVKKG-KYWMYCPWNA-N

SMILES: N(C(CC1=CC(Cl)=C(Cl)C=C1)=O)(C)[C@@H]2[C@H](C[C@@]3(CC2)CCCO3)N4CCCC4.S(C)(=O)(=O)O

Synonyms:

• Benzeneacetamide, 3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, rel-, methanesulfonate (1:1)
• U 62066E
• 1-Oxaspiro[4.5]decane, benzeneacetamide deriv.
• Benzeneacetamide, 3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, (5R,7S,8S)-rel-, monomethanesulfonate
• Benzeneacetamide, 3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, (5α,7α,8β)-(±)-, monomethanesulfonate