CAS 872511-34-7

3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea

Description:

The chemical substance known as "3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea," with the CAS number 872511-34-7, is a synthetic organic compound that belongs to the class of urea derivatives. It features a complex molecular structure characterized by multiple functional groups, including a urea moiety, aromatic rings, and halogen substituents. The presence of dichloro and dimethoxy groups suggests potential biological activity, possibly influencing its pharmacological properties. This compound is often studied in medicinal chemistry for its potential applications in drug development, particularly in targeting specific biological pathways or receptors. Its intricate structure may contribute to its solubility, stability, and interaction with biological systems. As with many synthetic compounds, understanding its characteristics, including its reactivity, solubility, and potential toxicity, is crucial for evaluating its suitability for therapeutic use. Further research is typically required to elucidate its mechanism of action and efficacy in relevant biological contexts.

Formula: C₂₆H₃₁Cl₂N₇O₃

InChI: InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)

SMILES: CCN1CCN(CC1)c1ccc(cc1)Nc1cc(ncn1)N(C)C(=Nc1c(c(cc(c1Cl)OC)OC)Cl)O

Synonyms:

• Nvp-Bgj398
• Bgj-398

BGJ398 (NVP-BGJ398)

CAS: 872511-34-7

Formula: C₂₆H₃₁Cl₂N₇O₃

Purity: %

Color and Shape: Solid

Molecular weight: 560.4754

Ref: IN-DA00GU4Z

3-(2,6-Dichloro-3,5-Dimethoxyphenyl)-1-[6-[4-(4-Ethylpiperazin-1-Yl)Anilino]Pyrimidin-4-Yl]-1-Methylurea

CAS: 872511-34-7

3-(2,6-Dichloro-3,5-Dimethoxyphenyl)-1-[6-[4-(4-Ethylpiperazin-1-Yl)Anilino]Pyrimidin-4-Yl]-1-Methylurea

Purity: 98%

Molecular weight: 560.48g/mol

Ref: 54-OR1024382

Infigratinib

CAS: 872511-34-7

Infigratinib

Purity: ≥98%

Molecular weight: 560.48g/mol

Ref: 54-BUP15525

NVP-BGJ398

CAS: 872511-34-7

Ref: 7W-GW3341

Infigratinib

CAS: 872511-34-7

Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and

Formula: C₂₆H₃₁Cl₂N₇O₃

Purity: 98% - 98.97%

Color and Shape: Solid

Molecular weight: 560.48

Ref: TM-T1975

NVP-BGJ398

CAS: 872511-34-7

Inhibits FGFR family of kinases; antineoplastic; anti-angiogenic

Formula: C₂₆H₃₁Cl₂N₇O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 560.48 g/mol

Ref: 3D-FD46729

BGJ 398

Controlled Product

CAS: 872511-34-7

Applications BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
References Guagnano, V., et al.: J. Med. Chem., 54, 7066 (2011); Konecny, G., et al.: Mol. Cancer Ther., 12, 632 (2013)

Formula: C₂₆H₃₁Cl₂N₇O₃

Color and Shape: Neat

Molecular weight: 560.48

Ref: TR-B367000