CAS 873054-44-5: Ivacaftor

Description: Ivacaftor is a pharmaceutical compound primarily used in the treatment of cystic fibrosis, particularly in patients with specific mutations in the CFTR gene. It functions as a CFTR potentiator, enhancing the function of the defective protein produced by the CFTR gene. Ivacaftor is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its complex structure. The substance is typically administered orally and is known for its relatively high bioavailability. It exhibits a moderate solubility in water and is often formulated in tablet form for ease of use. Ivacaftor's mechanism of action involves binding to the CFTR protein, facilitating the opening of the chloride channels, which helps to improve ion transport and mucus clearance in the lungs. The drug has been shown to significantly improve lung function and reduce pulmonary exacerbations in patients with the appropriate genetic profile. As with any medication, it is essential to monitor for potential side effects and drug interactions during treatment.

Formula: C₂₄H₂₈N₂O₃

InChI: InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)

InChI key: InChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N

SMILES: O=C(NC1=CC(O)=C(C=C1C(C)(C)C)C(C)(C)C)C2=CNC=3C=CC=CC3C2=O

Synonyms:

• 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-
• Ivacaftor
• Kalydeco
• N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide
• N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
• N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide
• N-[2,4-Di(tert-butyl)-5-hydroxyphenyl]-4-oxo-1H,4H-quinoline-3-carboxamide
• Vx-770

N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide

CAS: 873054-44-5

• Formula: C₂₄H₂₈N₂O₃
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 392.4907

N-[2,4-Bis(Tert-Butyl)-5-Hydroxyphenyl]-1,4-Dihydro-4-Oxo-3-Quinolinecarboxamide

CAS: 873054-44-5

• Purity: 99%
• Molecular weight: 392.49g/mol

Ivacaftor

CAS: 873054-44-5

• Formula: C₂₄H₂₈N₂O₃
• Purity: ≤ 0.5%
• Color and Shape: White to off-white powder
• Molecular weight: 392.49

Ivacaftor

CAS: 873054-44-5

• Purity: ≥98%
• Molecular weight: 392.49g/mol

Ivacaftor

CAS: 873054-44-5

• Formula: C₂₄H₂₈N₂O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 392.50

Ivacaftor

CAS: 873054-44-5

• Formula: C₂₄H₂₈N₂O₃
• Color and Shape: Neat
• Molecular weight: 392.49

Ivacaftor

CAS: 873054-44-5

Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR …

• Formula: C₂₄H₂₈N₂O₃
• Purity: 99% - 99.98%
• Color and Shape: Solid
• Molecular weight: 392.49

Ivacaftor

CAS: 873054-44-5

Applications Ivacaftor is used in the treatment of cystic fibrosis. References Clancy, J. et al.: …

• Formula: C₂₄H₂₈N₂O₃
• Color and Shape: Off-White
• Molecular weight: 392.49

IVACAFTOR

CAS: 873054-44-5

• Purity: 95.0%
• Color and Shape: Liquid, No data available.
• Molecular weight: 392.4989929199219

Ivacaftor

CAS: 873054-44-5

Activates CFTR channels

• Formula: C₂₄H₂₈N₂O₃
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 392.49 g/mol