CAS 873697-71-3: Omecamtiv mecarbil
Description:Omecamtiv mecarbil is a novel small molecule classified as a cardiac myosin activator, primarily investigated for its potential in treating heart failure. It functions by selectively enhancing the contractility of cardiac muscle without increasing intracellular calcium levels, which helps to improve cardiac output while minimizing the risk of arrhythmias. The compound is characterized by its unique mechanism of action that targets the myosin motor protein, thereby increasing the efficiency of cardiac muscle contraction. Omecamtiv mecarbil has been the subject of various clinical trials, demonstrating its ability to improve heart function in patients with reduced ejection fraction. Its pharmacokinetic profile indicates moderate absorption and a half-life that allows for once-daily dosing. Additionally, it is important to note that while promising, the long-term effects and safety profile of omecamtiv mecarbil continue to be evaluated in ongoing research. Overall, this compound represents a significant advancement in the pharmacological management of heart failure, aiming to enhance the quality of life for affected patients.
Formula:C20H24FN5O3
InChI:InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)
InChI key:InChIKey=RFUBTTPMWSKEIW-UHFFFAOYSA-N
SMILES:O=C(OC)N1CCN(CC=2C=CC=C(NC(=O)NC3=CN=C(C=C3)C)C2F)CC1
- Synonyms:
- Ck-1827452
- Methyl 4-[[2-fluoro-3-[N′-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate
- Omecamtiv mecarbil
- 1-Piperazinecarboxylic acid, 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester
