CAS 874-14-6

1,3-Dimethyluracil

Description:

1,3-Dimethyluracil is a chemical compound classified as a pyrimidine derivative, specifically a methylated form of uracil. Its molecular formula is C7H8N2O2, and it features two methyl groups attached to the nitrogen atoms at positions 1 and 3 of the uracil ring. This modification influences its biological activity and solubility. The compound is typically a white to off-white crystalline solid, and it is soluble in polar solvents such as water and alcohols. 1,3-Dimethyluracil has been studied for its potential applications in biochemistry and pharmacology, particularly in relation to its effects on nucleic acid metabolism and its role as a potential therapeutic agent. Its structure allows it to interact with various biological systems, making it of interest in research related to cancer and antiviral therapies. As with many chemical substances, proper handling and safety precautions are essential due to its biological activity.

Formula: C₆H₈N₂O₂

InChI: InChI=1S/C6H8N2O2/c1-7-4-3-5(9)8(2)6(7)10/h3-4H,1-2H3

InChI key: InChIKey=JSDBKAHWADVXFU-UHFFFAOYSA-N

SMILES: O=C1N(C)C(=O)C=CN1C

Synonyms:

• 1,3-Dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• 1,3-Dimethyl-1H,3H-pyrimidine-2,4-dione
• 1,3-Dimethyl-2,4(1H,3H)-pyrimidinedione
• 1,3-Dimethyl-2,4-Pyrimidinedione
• 1,3-dimethylpyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-
• N,N′-Dimethyluracil
• N¹,N³-Dimethyluracil
• NSC 401858
• Uracil, 1,3-dimethyl-
• 1,3-Dimethyluracil

1,3-Dimethyluracil

CAS: 874-14-6

Formula: C₆H₈N₂O₂

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 140.14

Ref: 3B-D0808

1,3-Dimethyluracil

CAS: 874-14-6

Formula: C₆H₈N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 140.1399

Ref: IN-DA003DKK

1,3-Dimethyluracil

CAS: 874-14-6

Formula: C₆H₈N₂O₂

Molecular weight: 140.14

Ref: 7W-GK9284

1,3-Dimethyl Uracil

CAS: 874-14-6

Formula: C₆H₈N₂O₂

Molecular weight: 140.14

Ref: 4Z-U-0518

1,3-Dimethyluracil

CAS: 874-14-6

1,3-Dimethyluracil

Formula: C₆H₈N₂O₂

Purity: ≥95%

Color and Shape: white crystalline solid

Molecular weight: 140.14g/mol

Ref: 54-OR27441

1,3-Dimethyluracil

CAS: 874-14-6

1,3-Dimethyluracil is a uracil derivative that is used as a hydrogen-bond donor, which helps to repair DNA. It has been shown to have a kinetic isotope effect in the deuterium isotope effect studies. The carbonyl group of 1,3-dimethyluracil can form hydrogen bonds with the guanine base in DNA and lead to the formation of an adduct. This adduct can be repaired by nucleotide excision repair when it forms a dimer with another 1,3-dimethyluracol molecule or by base excision repair when it forms a dimer with another purine or pyrimidine base.
Aqueous solutions of 1,3-dimethyluracil are stable for short periods of time but decompose rapidly on heating. X-ray crystal structures show that 1,3-dimethyluracil binds to hydrochloric acid and x-ray crystallographic analysis

Formula: C₆H₈N₂O₂

Purity: Min. 95%

Color and Shape: Off-White Slightly Brown Powder

Molecular weight: 140.14 g/mol

Ref: 3D-FD06288

1,3-Dimethyluracil

CAS: 874-14-6

Formula: C₆H₈N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 140.142

Ref: 10-F018492