CAS 87418-35-7

3'-Fluoro-2',3'-Dideoxyadenosine

Description:

3'-Fluoro-2',3'-Dideoxyadenosine, commonly referred to as FDA, is a synthetic nucleoside analog of adenosine. It is characterized by the presence of a fluorine atom at the 3' position of the ribose sugar, which replaces the hydroxyl group typically found in natural nucleosides. This modification imparts unique properties, making it a valuable compound in antiviral and anticancer research. The absence of the 2' and 3' hydroxyl groups in its structure contributes to its ability to inhibit viral replication by interfering with nucleic acid synthesis. FDA has been studied for its potential effectiveness against various viral infections, including HIV, due to its mechanism of action as a chain terminator during reverse transcription. Additionally, its structural modifications enhance its stability and bioavailability compared to natural nucleosides. As a result, 3'-Fluoro-2',3'-Dideoxyadenosine represents an important tool in medicinal chemistry and pharmacology, particularly in the development of therapeutic agents targeting viral diseases.

2',3'-Dideoxy-3'-fluoroadenosine

CAS: 87418-35-7

Nucleoside Derivatives - Fluoro-modified nucleosides; 2’,3’-Dideoxy nucleosides; Drugs and Inhbitors; Antiviral agent

Formula: C₁₀H₁₂FN₅O₂

Color and Shape: Solid

Molecular weight: 253.23

Ref: TM-TNU1248

2',3'-Dideoxy-3'-fluoroadenosine

CAS: 87418-35-7

2',3'-Dideoxy-3'-fluoroadenosine (ddFdA) is an antiviral drug that has been shown to be effective against HIV and other viruses. It is a synthetic nucleoside analogue of the natural purine adenosine. ddFdA inhibits the synthesis of viral RNA and DNA by competitively inhibiting the enzyme ribonucleotide reductase, thereby blocking DNA synthesis. The drug has shown significant activity in humans with immunodeficiency, but also has toxic effects on lymphocytes. ddFdA is synthesised from 2',3'-dideoxyadenosine (ddAdo), which is produced by the action of adenosinase on adenosine. In humans, ddFdA is converted to dideoxyadenosine triphosphate (ddATP), which inhibits cellular proliferation.

Formula: C₁₀H₁₂FN₅O₂

Purity: Min. 95%

Molecular weight: 253.23 g/mol

Ref: 3D-ND80474