CAS 874819-74-6

Toceranib Phosphate

Description:

Toceranib phosphate is a small molecule drug primarily used in veterinary medicine, particularly for the treatment of certain types of cancers in dogs. It is a tyrosine kinase inhibitor that targets specific pathways involved in tumor growth and angiogenesis, making it effective against tumors that express the receptor for vascular endothelial growth factor (VEGF). The compound is known for its ability to inhibit the activity of various receptor tyrosine kinases, which play a crucial role in cell signaling related to growth and proliferation. Toceranib phosphate is typically administered orally and is absorbed well in the gastrointestinal tract. Its pharmacokinetics indicate a moderate half-life, allowing for once-daily dosing in clinical settings. Common side effects may include gastrointestinal disturbances, lethargy, and changes in blood cell counts, necessitating monitoring during treatment. Overall, toceraib phosphate represents a significant advancement in the management of canine tumors, providing a targeted therapeutic option that can improve outcomes for affected animals.

Synonyms:

• 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide,phosphoric acid
• 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide phosphate

Toceranib phosphate

CAS: 874819-74-6

Formula: C₂₂H₂₈FN₄O₆P

Purity: 98%

Color and Shape: Solid

Molecular weight: 494.4531

Ref: IN-DA00GU75

Toceranib Phosphate

CAS: 874819-74-6

Toceranib Phosphate

Purity: 97%

Molecular weight: 494.46g/mol

Ref: 54-PC109154

Toceranib Phosphate

CAS: 874819-74-6

Toceranib Phosphate

Purity: ≥98%

Molecular weight: 494.45g/mol

Ref: 54-BUP11203

Toceranib Phosphate

CAS: 874819-74-6

Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.

Formula: C₂₂H₂₈FN₄O₆P

Purity: 98.56%

Color and Shape: Solid

Molecular weight: 494.45

Ref: TM-T7394

Toceranib Phosphate

Controlled Product

CAS: 874819-74-6

Applications Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.
References Conte, L. A.: U.S. Pat. Appl. Publ. (2020), US 20200345687 A1

Formula: C₂₂H₂₅FN₄O₂·H₃PO₄

Color and Shape: Neat

Molecular weight: 396.47 + (97.99)

Ref: TR-T525503

Toceranib phosphate - Bio-X ™

Controlled Product

CAS: 874819-74-6

Toceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).

Formula: C₂₂H₂₅FN₄O₂·H₃O₄P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 494.45 g/mol

Ref: 3D-BT162330

Toceranib phosphate

Controlled Product

CAS: 874819-74-6

Toceranib phosphate is a tyrosine kinase inhibitor that is used to treat a variety of cancers. It has been shown to be an effective treatment for solid tumours, such as lung cancer and renal cell carcinoma. Toceranib has also been shown to have anti-angiogenic properties, which may contribute to its antitumor response. One study found that the drug is cleared by the liver and eliminated by the kidneys, with a half-life of approximately 15 hours. A phase II clinical trial found that Toceranib was well tolerated in patients with metastatic breast cancer who had previously been treated with anthracyclines and taxanes. The most common adverse effects were diarrhea (in 8% of subjects), hypertension (6%), and nausea (3%).

Formula: C₂₂H₂₅FN₄O₂•H₃O₄P

Purity: 90%

Color and Shape: Powder

Molecular weight: 494.45 g/mol

Ref: 3D-FT104292